I'm so happy to have found this board, I can't stop asking questions. I have also been reading and reading old posts, so I hope I'm notbeing too repetitive. Anyone else have ok/high cortisol levels, but a poor response on the ACTH challenge? I was tested in the a.m.- cortisol was 22.4. The level only went to 24 after the ACTH injection (should double). The nurse said she had never seen anything like that (hihg cortisol, but no response to ACTH). My doctor, who is NOT easy to talk to, mumbled when I asked if the intial level was hgihg, then put me on Cortef. I felt FANTASTIC for 1 week, then got horribly Depressed. I'd love to try going up on the Cortef (the intial pos. results seem to have faded, but I'm worried about getting any more Depressed. Shoudl I even be on Cortef with an initial level of 22.4 in the a.m.? signed, worried, confused, depressed, and JUST WANTING TO FEEL BETTER!!