36 Serum cytokine and chemokine profiles...

Discussion in 'Lyme Disease Archives' started by ChuckNBerkeley, Apr 8, 2009.

  1. ChuckNBerkeley

    ChuckNBerkeley New Member

    So how does this mesh with Lyme?

    whittlemore peterson diagnostic me/cfs test. news report form you tube
    4/8/09 7:10 AM

    <Quote>In this study our aim was to subgroup ME/CFS patients based on serum chemokine and cytokine profiles with the ultimate goal of establishing disease parameters on a molecular level that correlate with distinct disease phenotypes. We used suspension antibody microarrays of 25-cytokines and chemokines on a Luminex platform for serum profiling of 168 ME/CFS patients and 140 healthy controls. Our analysis has revealed distinct pathogen associated signatures with significant 5- to 200-fold differences between patients and controls for the inflammatory serum chemokines IL-8, IP-10, MIP-a and MIP-1b, as well as the pro inflammatory cytokines IL-6, TNFa and IL-1b.

    Moreover, our data shows for the first time in ME/CFS a cytokine and chemokine profile, which suggests a TH17 shift in subgroups of our cohort. We conclude that cytokine and chemokine patterns in subgroups of ME/CFS can be used diagnostically, as serum biomarkers to stratify patients for appropriate anti-inflammatory, antimicrobial and antiviral therapeutics.<Unquote>