I guess I have a difficult time understanding a "disease" that has no known cause. Without a cause it is what it is...a syndrome identified by a set of symptoms. I, and my family have suffered for years with Lyme Complex, an infection that is caused by an array of tick borne infections, i.e., Babesiosis, Lyme Disease, Bartonella, Rocky Mountain Spotted Fever, Ehrlichiosis, Babesia WA1, etc. THe list grows longer every day. Given that the tests for these are very unreliable it is essentially a clinical diagnosis based on a set of symptoms that include chronic fatigue, Neurological damage, neurological pain, muscle wasting, immune dysfunction which leads to opportunistic viral infections like herpes 6 and 8, micoplasma, etc. I have yet to find a person with tertiary lyme complex that did not suffer from the same set of symptoms that CFS and Fibromyalgia sufferers display. My spouse suffers from Neuro pain, muscle weakness, memory loss, horrific headaches, a compromised immune system that has led to opportunistic viral infections like Herpes 6 and 8, micoplasma, ringing in the ears, extreme chronic fatigue, sensitivity to sound,light, and touch, depression, anxiety, recurring fevers and sweats, and on and on. Doesn't this sound an awful lot like CFS? She has been treated with anti virals, antibiotics, and anti malarial drugs and had achieved almost complete recovery for two years before relapsing after a hysterectomy four years ago. She is again on the road to recovery after finding that she now has a recently discovered form of Babesia, WA1. How does one tell the difference between CFS and Lyme complex? Is there a difference? Maybe we should call CFS Lyme Complex??. Could it be that the only difference between the two is the doctor who diagnoses the disease. I welcome any and all feedback as to the unique characteristics of CFS and what leads to a definitive diagnosis of it. If you consider my comments naive and ignorant then please enlighten me. Thanks you and God Bless all who suffer with any of these horrible, life destroying diagnoses.