A metabolic basis for Fibro....- Articlt

Discussion in 'Fibromyalgia Main Forum' started by COOKIEMONSTER, Aug 13, 2003.

  1. COOKIEMONSTER

    COOKIEMONSTER New Member

    A metabolic basis for fibromyalgia and its related disorders: the possible role of resistance to thyroid hormone.

    Journal: Med Hypotheses. 2003 Aug;61(2):182-9.

    Authors: Garrison RL [1], Breeding PC.

    NLM Citation: PMID: 12888300

    It has long been recognized that the symptom complex of fibromyalgia can be seen with hypothyroidism. Hypothyroidism may been categorized, like diabetes, into type I (hormone deficient) and type II (hormone resistant).

    Most cases of fibromyalgia fall into the latter category. The syndrome is reversible with treatment, and is usually of late onset. It is likely more often acquired than due to mutated receptors. Now that there is evidence to support the hypothesis that fibromyalgia may be due to thyroid hormone resistance, four major questions appear addressable.

    First, can a simple biomarker be found to help diagnose it? Second, what other syndromes similar to Fibromyalgia may share a thyroid-resistant nature? Third, in non-genetic cases, how is resistance acquired? Fourth, what other methods of treatment become available through this new understanding?

    Preliminary evidence suggests that serum hyaluronic acid is a simple, inexpensive, sensitive, and specific test that identifies fibromyalgia. Overlapping symptom complexes suggest that chronic fatigue syndrome, Gulf war syndrome, premenstrual syndrome, post traumatic stress disorder, breast implant silicone sensitivity syndrome, bipolar affective disorder, systemic candidiasis, myofascial pain syndrome, and idiopathic environmental intolerance are similar enough to fibromyalgia to merit investigation for possible thyroid resistance.

    Acquired resistance may be due most often to a recently recognized chronic consumptive coagulopathy, which itself may be most often associated with chronic infections with mycoplasmids and related microbes or parasites. Other precipitants of thyroid resistance may use this or other paths as well.

    In addition to experimentally proven treatment with supraphysiologic doses of thyroid hormone, the thyroid-resistant disorders might be treatable with anti-hypercoagulant, anti-infective, insulin-sensitizing, and hyaluronolytic strategies.

  2. tansy

    tansy New Member

    Just what I needed for my next GP appointment. Highlights thyroid problems but connected to hypercoagualtion and infections which are useful in my case.

    Does anyone know what hyaluronolytic strategies are. I've come across the other terms numerous times but this is a new one for me.

    Cheers

    Tansy
    [This Message was Edited on 08/13/2003]