Acetyl-glutathione

Discussion in 'Fibromyalgia and ME & Chronic Fatigue Syndrome' started by Elisa, Jan 8, 2013.

  1. elliespad

    elliespad Member

    Hi Elisabeth, I do believe my stomach pain has finally completely resolved, although I am sure it was not actually my stomach, or at least not indigestion type pain. I've eaten Indian food and HOT Japones about 5 times since this odd pain started, and it never worsened it.

    I think I'll start back up tomorrow with the Acetyl-Glutathione. Wishing myself luck.

  2. IanH

    IanH Active Member

    This paper suggests esterized glutathione may work better than GSH. So maybe acetyl glutathione, which is a simple glutathione-ester is better absorbed and therefore has higher ROS control. Its a very technical animal study but nonetheless it is pointing in the right direction.

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055288?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed%3A+plosone%2FPLoSONE+%28PLoS+ONE+Alerts%3A+New+Articles%29
  3. IanH

    IanH Active Member

    We use sublingual GSH and here a re some recent measures we have taken from patients.

    Serum GSH levels in 12 people with ME/CFS averaged 0.41 mmol/L. This is an abnormally low level.
    After sublingual 100mg dose of glutathione (+riboflavin) the GSH levels were:

    3 Hours: 0.63 mmol/L
    6 Hours: 0.69 mmol/L
    24 Hours: 0.64 mmol/L

    In addition the malondialdehyde levels were:

    pre dose: 1.61 micromol/L (quite high)
    6 HOurs: 1.51 micromol/L
    24 Hours: 1.30 micromol/L

    Malondiadehyde levels are taken as a general measure of oxidative stress and toxin clearance. From these results you can see that people with ME/CFS have high levels of malondialdehyde (probably because of the GSH depletion) but that dosage with sublingual GSH reduces the levels. This means the GSH is having an effect, surprisingly quickly.

    Therefore, we regard sublingual GSH as effective in people with ME/CFS.

    GSH in ME/CFS whatever form you take will produce no change in energy levels but does seem to help people with FM who are affected by chemical exposure where those chemicals (pesticides and petrochemicals) increase their pain. Similarly those with MCS can be helped IF they can tolerate it.

    It is also important to remember that serum levels are only a proxy measure as GSH is effective only intracellulary and mainly in mitochondria.

    When taken with NAC and vitamin D it is more effective. (Because vitamin D raises GSH levels by protecting it from degradation).

    Instead of arguing about which form is most effective just take what you can afford but avoid swallowing doses.
  4. mbofov

    mbofov Active Member

    Source Naturals makes a sublingual form of GSH called Chem Defense, which has 50 mg. reduced glutathione, 120 mcg. of molybdenum and 1.6 mg. of riboflavin. I first tried taking this several years ago and could not tolerate it, made me detox too much. But I'm taking it now with no problem - something's working better! It's cheap too, $11 or $12 a bottle for 90 tabs.

    Mary
  5. tydings

    tydings Member

    I have finally come to the acceptance that I have CFS. I was first diagnosed in 2006. I have had all tests run and they come out normal. I can not exert myself through exercise or for that matter even cleaning my house, or I will regret it sometimes for days and days. I have been bedridden with CFS. Has anyone tried the NAC only? There is a study out by Cornell and they are having test subjects go to New York and try out a supplement. I have turned in my paperwork to go and I live in Kansas City. Has anyone else tried any testing or this test? I figured for the cost of all the supplements I might as well fly there. My main complaint is fatigue, not the pain or other symptoms that can occur with CFS.

    Joi
  6. TigerLilea

    TigerLilea Member

    I have used NAC as a part of the Martin Pall protocol. I didn't find that it made any difference to my fatigue. Like you, my main complaint is also the fatigue. That is 90% of my symptoms - fatigue/post-exertional malaise.
  7. tydings

    tydings Member

    I have not heard of the Martin Pall protocol. Did it help?
  8. TigerLilea

    TigerLilea Member

    For me, no, it didn't. However, I have met some people via the internet that found that for them it did reduce some of their symptoms. It also works well for people with MCS.
  9. IanH

    IanH Active Member

    [quote="tydings"

    Have you tried the mitochondrial dysfunction treatment? If PEM and general exhaustion is the problem then this is the best protocol. NAC will not help your energy levels, nor will glutathione.