That's all very interesting stuff, and quite a coincidence about Dr. Jefferies, who was my first mentor in all of this after my "accidental" cortisol "cure" some 20 years ago. After coming out of a 7-year CFS bout with my first perfect night's sleep in almost as many years following hydrocortisone injection and prednisone all given for severe asthma/bronchitis, I went straight to the UCI science library and found Jefferies' book (I had been in a total brain-fog/no sleep/headache state for years and hadn't read or researched anything). We had several correspondences (pre-internet!) and even a nice phone talk or two. He was a wonderful, caring doctor and one of the first researchers testing cortisol supplementation. I'm curious as to what started your downward slide healthwise, and what your symptoms are? A simple blood-glucose tester would be useful also as you can check your fasting morning level. Jefferies was one of the only doctors to emphasize "non-reactive" hypoglycemia as a possible indicator of low cortisol (or burned-out cortisol receptors). take care!