I had a severe allergic reaction to cashews (I knew I was allergic, but accidentally ate a cookie with them in it) that sent me to the emergency room a month and a half ago. I recovered after a about a week (including 4 days on prednisone). I still had slight puffiness in my face for almost two weeks. Now, for the past 30 days or so I have had an increase in migraines that don't respond to imitrex, as well as a severe flare up in my fibromyalgia pain and fatigue. My primary care doctor just gave me a higher dose of imitrex to try, and sent me to make an appointment for a followup with an allergist. I have been reading lately about cytokines, but I admit I don't really know what they are or what they do or how they relate to allergies and fibromyalgia. But I am now wondering if my severe reaction put my body into overdrive somehow, and that is the cause of my recent flare in pain? Anyone have any ideas? Unfortunately my appointment with the allergist is not for another few weeks. Anyone else have acute food allergies notice anything like this happen?