Aluminium Induced Mitochondrial dysfunction

Discussion in 'Fibromyalgia Main Forum' started by tansy, Jun 26, 2008.

  1. tansy

    tansy New Member

    1: Cell Physiol Biochem. 2007;20(5):627-38.

    Links Aluminum-induced mitochondrial dysfunction leads to lipid accumulation in human hepatocytes: a link to obesity.Mailloux R, Lemire J, Appanna V.
    Department of Chemistry and Biochemistry, Laurentian University, Ontario, Canada.

    Mitochondrial dysfunction is the cause of a variety of pathologies
    associated with high energy-requiring tissues like the brain and

    Here we show that aluminum (Al) perturbs oxidative-ATP
    production in human hepatocytes (HepG2 cells). This Al-induced
    mitochondrial dysfunction promotes enhanced lipogenesis and the
    accumulation of the very low density lipoprotein (VLDL).

    HepG2 cells secreted more cholesterol, lipids and proteins than
    control cells. The level of apolipoprotein B-100 (ApoB-100) was
    markedly increased in the culture medium of the cells exposed to Al.

    (13)C-NMR and HPLC studies revealed a metabolic profile favouring
    lipid production and lowered ATP synthesis in Al-treated cells.

    Electrophoretic and immunoblot analyses pointed to increased
    activities and expression of lipogenic enzymes such as glycerol 3-
    phosphate dehydrogenase (G3PDH), acetyl CoA carboxylase (ACC) and ATP-
    citrate lyase (CL) in the hepatocytes exposed to Al, and a sharp
    diminution of enzymes mediating oxidative phosphorylation.

    elicited the maximal secretion of VLDL in the Al-challenged cells.

    These results suggest that the Al-evoked metabolic shift favours the
    accumulation of lipids at the expense of oxidative energy production
    in hepatocytes. Copyright (c) 2007 S. Karger AG, Basel.

    PMID: 17762189 [PubMed - indexed for MEDLINE]

    [This Message was Edited on 06/26/2008]
  2. Rafiki

    Rafiki New Member

    Well, this is disturbing. You know that little mite problem I mentioned to you? Well, the only thing that seems to get rid of the little blighters is antiperspirant with aluminum!!! Yes, I know. I've done so much research. Most concerned about the wee dog, truth be told.

    But, yeah, I'm breathing in great clouds of aluminium chlorolhydrate (I think) several times a day.

    Not good, huh? No.


  3. tansy

    tansy New Member

    what a conundrum. ;-) Well I guess that shows how powerful/toxic aluminium can be.

    In your research have you come across tea tree? Might be worth trying. Two contraindications of tea tree are it should not be used if MRSA is present since it can make the infection worse and secondly it has been reported to be toxic to cats if used topically on them.

    The efficacy of tea tree depends upon the brand; there's info on the net about how to choose an effective tea tree product. I know you have a lot on your plate just now so I can post some info below for you.

    My son became seriously ill as a result of multiple midge bites last month; he's now using a natural (non deet) insect repellant; tea tree oil is one of the ingredients.

    Since I had problems with multiple midge bites a week later I bought a natural oil based insect repellant made in Germany. It worked but the smell was so strong I reckoned it would act as a human repellent too! So Now I am using just tea tree oil; it works and just smells clean and fresh in a slightly antiseptic way

    tc, Tansy
    [This Message was Edited on 06/26/2008]
  4. tansy

    tansy New Member

    Hi Rakiki

    You want to look at the Cineole and Terpinen-4-ol numbers.

    Cineole: The lower the number the better. Tree oils with high cineole content are thought to be of poor quality and more likely to cause skin irritation.

    Terpinen-4-ol: The higher the number the better. Terpinen-4-ol appears responsible for most of the antimicrobial activity of tea tree oil.

    Australian standard for Tea Tree Oil (AS2782-1985) requires a maximum cineol content of 15% and a minimum terpinen-4-ol of 30%.

    tc, Tansy

  5. Rafiki

    Rafiki New Member

    I always have Tea Tree Oil! Tea Tree oil is amazing stuff. I have used it to completely fix very bad toenail fungus of many years duration -- my toes are now beautiful! I use it for spots as does my kid -- if a young woman is willing to put something that smells like terpentine on her face, you know it's really effective.

    Didn't know about MERSA. Very disappointed as I had hoped Tea Tree oil would keep me safe from MERSA and everything else. I have truly believed it to be a miracle substance.

    It does seem to confuse the mites since they communicate through pheremones(sp?). It prevents them from swarming and I use TTO mixed with orange lotion to keep them out of my hair, nose, eyes (keep the TTO out of eyes, too) and ears. Doesn't kill them or not efficiently. Only things, aside from heavy duty toxins, that kill them are aluminum, which dehydrates them, borax also dehydrates but harder to reach them and ammonia.

    Apres le deluge -- mites!

  6. Rafiki

    Rafiki New Member

    Well, it seems we're doing the same thing with TTO that we've done with other effective antibiotics. We are so foolish! It's the small doses of TTO found in soaps and shampoos that have contributed to the resistance just as antibacterial soaps do.

    Collectively, we are not smart animals!

  7. Juloo

    Juloo Member

    Just marking so I can read when I get home!
  8. tansy

    tansy New Member

    A role for the body burden of aluminium in vaccine-associated
    macrophagic myofasciitis and chronic fatigue syndrome.

    Journal: Med Hypotheses. 2008 Nov 10. [Epub ahead of print]

    Authors: Exley C, Swarbrick L, Gherardi RK, Authier FJ.

    Affiliation: Birchall Centre for Inorganic Chemistry and Materials
    Science, Lennard-Jones Laboratories, Keele University, Staffordshire
    ST5 5BG, UK.

    NLM Citation: PMID: 19004564

    Macrophagic myofasciitis and chronic fatigue syndrome are severely
    disabling conditions which may be caused by adverse reactions to
    aluminium-containing adjuvants in vaccines. While a little is known
    of disease aetiology both conditions are characterised by an aberrant
    immune response, have a number of prominent symptoms in common and
    are coincident in many individuals.

    Herein, we have described a case of vaccine-associated chronic
    fatigue syndrome and macrophagic myofasciitis in an individual
    demonstrating aluminium overload. This is the first report linking
    the latter with either of these two conditions and the possibility is
    considered that the coincident aluminium overload contributed
    significantly to the severity of these conditions in this individual.

    This case has highlighted potential dangers associated with
    aluminium-containing adjuvants and we have elucidated a possible
    mechanism whereby vaccination involving aluminium-containing
    adjuvants could trigger the cascade of immunological events which are
    associated with autoimmune conditions including chronic fatigue
    syndrome and macrophagic myofasciitis.

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