An Interesting Article On Sleep FM

Discussion in 'Fibromyalgia Main Forum' started by suzetal, Apr 16, 2006.

  1. suzetal

    suzetal New Member

    ===Sleep disturbance===
    The sleep disturbance theory postulates that fibromyalgia is related to [[sleep]] quality. [[Electroencephalography]] (EEG) studies have shown that people with fibromyalgia lose deep sleep[http://www.arc.org.uk/about_arth/booklets/6013/6013.htm]. Circumstances that interfere with "stage 4" deep sleep (such as [[drug use]], pain, or [[anxiety]]) appear to be able to cause or worsen the condition.

    According to the sleep disturbance theory, an event such as a trauma or illness causes sleep disturbance and, possibly, some sort of initial chronic pain. These initiate the disorder. The theory supposes that "stage 4" sleep is critical to the function of the [[nervous system]], as it is during that stage that certain neurochemical processes in the body 'reset'. In particular, pain causes the release of the [[neuropeptide]] [[substance P]] in the [[spinal cord]], and substance P has the effect of amplifying pain and causing nerves near the initiating ones to become more sensitive to pain. Under normal circumstances, this just causes the area around a wound to become more sensitive to pain, but, if pain becomes chronic and body-wide, then this process can run out of control. The sleep disturbance theory holds that deep sleep is critical in order to reset the substance P mechanism and prevent this out-of-control effect.

    An interesting aspect of the sleep disturbance/substance P theory is that it explains "tender points" that are characteristic of fibromyalgia but which are otherwise enigmatic, since their positions don't correspond to any particular set of nerve junctions or other obvious body structures. The theory posits that these locations are more sensitive because the sensory nerves that serve them are positioned in the spinal cord to be most strongly affected by substance P. The theory also explains some of more general neurological features of fibromyalgia, since substance P is active in many other areas of the nervous system.

    Critics of the theory argue that it does not explain slow-onset fibromyalgia, fibromyalgia present without tender points, or patients without heightened pain symptoms, and a number of the non-pain symptoms present in the disorder.

    Also of interest is a possible connection between this theory and the theory that [[chronic fatigue syndrome]] and [[post-polio syndrome]] are due, at least in part to damage to the [[ascending reticular activating system]] of the [[reticular formation]]. This area of the brain, in addition to apparently controlling the sensation of fatigue, is known to control sleep behaviors and is also believed to produce some neuropeptides, and thus injury or imbalance in this area could cause both CFS and sleep-related fibromyalgia, explaining why the two disorders so often occur together.

    Found it interesting about not having tender points and having FM.

    This one is also very interesting post polio syndrome.Symptoms same as CFS and FM.


    Post-polio syndrome (PPS) is a condition that frequently affects survivors of poliomyelitis, a viral infection of the nervous system, after recovery from an initial paralytic attack of the virus. Typically the symptoms appear 20-40 years after the original infection, at an age of 35 to 60. Symptoms include new or increased muscular weakness, pain in the muscles, and fatigue.

    Post-polio patients are also often noted to have memory problems, various cognitive difficulties, and an increased sensitivity to anesthetics. Weight gain is also a frequently noted symptom, though it's hard to tell if this is due to the disorder directly or due to the decreased level of physical activity that usually accompanies the disorder.

    Fatigue is often the most disabling symptom, as often even slight exertion can produce disabling fatigue and also increase other symptoms.

    Diagnosis of post-polio syndrome can be difficult, since the symptoms are hard to separate from the original symptoms of polio and from the normal infirmities of aging. There is no laboratory test for post-polio syndrome, nor is there any other specific diagnostic, so diagnosis is usually a "diagnosis of exclusion" where other possible causes of the symptoms are eliminated.

    The precise mechanism that causes post-polio syndrome is unknown. It shares many features in common with myalgic encephalitis, a form of chronic fatigue syndrome that is apparently caused by viral infections, but unlike those disorders it tends to be progressive, and can cause tangible loss of muscle strength.

    One theory of the mechanism behind the disorder is that it is due to "neural fatigue" from overworked neurons. The original polio infection generally results in the death of a substantial fraction of the motor neurons controlling skeletal muscles, and the theory is that the remaining neurons are thus overworked and eventually wear out.

    Another theory holds that the original viral infection damages portions of the lower brain, possibly including the thalamus and hypothalamus. This somehow upsets the hormones that control muscle metabolism, and the result is a metabolic disorder similar to mitochondrial disorder that causes muscle pain and injury (via rhabdomyolysis) and also causes the fatigue.

    Treatment generally is limited to supportive measures, primarily leg braces and energy-saving devices such as powered wheelchairs, plus pain relievers, sleep aids, etc. However, some post-polio patients claim to have found significant relief using large amounts of various food supplements, primarily L-carnitine, CoQ10, and d-ribose.

    I never knew any of this.I have been up all night could not sleep so did a lot of reading.

    Sue






    [This Message was Edited on 04/17/2006]
  2. srh

    srh New Member

    I've read the article before. Interesting. There is also another one I read just a few days or week ago. (Who knows?)

    It was similar about the sleep & pain and also stated that the part of the brain that seems to be different in us with fm also makes us more sensitive to pain.

    There was a study done on Fm patients and normal patients and they were doing mri's on them. When they pinched to thumb nail of the FM's the brain activity for pain was much higher on all of them and lower on the normal one.

    I should write down where I read the stuff, b/c like everyone here, I hardly remember anything anymore. Sorry.
  3. pemaw54

    pemaw54 New Member

    in simple terms. That FM is a malfunction of the brain to the central nervous system in the spine.

    This was very interesting. Thank you for sharing

    Suzette
  4. tammy21

    tammy21 New Member

    interesting read.
    Tammy