Last Wednesday I had a cortisone injection into the tendon sheath of my left ring finger, to help a 'trigger' finger problem. This is the second injectin for this finger. The series of events after the shot was much the same as the first time, but I got smart and asked to be taken off work the next day so I could rest my hand. Good thing, as it has been very sore and swollen. Better tonight, though. I think this will help, at least for a couple or three months anyway, once the trauma of the shot wears off. The anomaly is that I think I have a systemic reaction to the cortisone. The dose is very small and very local, but still, I have felt agitated and anxious, my stomach has been irritated, and I've had some insomnia. These are the same reactions I had the last time I had a cortisone shot, and each time before when I had them in my right hand for the same problem there. The doc says it's impossible to react this way, that it is only a local injection. But I know how I feel! Is it me? Is it psychosomatic? I won't discuss this with the doc again, as he already blew me off once about this. I know I'm very sensitive to most medications, especially sedatives and pain meds. I still take Darvocet half at a time unless I am very desperate and know I can sleep for many hours and not worry about a 'hang over' in the morning. Anyone else have this problem? Please tell me it's not just me!!!! Puzzled, Beth.