Antibiotics Treatment - a real education for CF + FM

Discussion in 'Fibromyalgia Main Forum' started by Rozmund, Nov 19, 2002.

  1. Rozmund

    Rozmund New Member


    Why I Prescribe Antibiotics to Patients with Chronic Fatigue Syndrome, Fibromyalgia,
    Multiple Chemical Sensitivity, and Other Autoimmune Diseases

    Part of email newsletter I received from ProHealth today.
    11-20-2002

    By Gabe Mirkin M.D.

    Before I prescribe any medication, I ask myself whether it will help or hurt. All of the
    autoimmune diseases cause severe disability. Conventional medications neither cure
    these diseases nor stop the progressive destruction that they cause. Doctors
    prescribe immune suppressives that sometimes have deadly effects. Antibiotics are
    far safer that the drugs conventionally used to treat these diseases. So, if antibiotics
    can be shown to help control these diseases, they should be used long before a
    doctor thinks of using the conventional immune suppressives.

    When a germ gets into your body, you are supposed to produce cells and proteins
    called antibodies that attach to and kill that germ. These diseases are felt by many
    doctors to be caused by your own immunity. Instead of doing its job of killing germs,
    your immunity attacks your own tissue. If it attacks your joints, it's called reactive
    arthritis; if it attacks your intestines, it’s called Crohn’s disease; your colon, it’s called
    ultra ulcerative colitis; and if it fills your lungs with mucous, it’s called late onset
    asthma. I do not believe that your immunity is that stupid.

    Accumulating data show that all of these conditions can be caused by infection. Many
    diseases that were thought to be autoimmune turn out to be infections: stomach
    ulcers are caused by bacterium, helicobacter pylori and others; multiple sclerosis may
    be caused by HHS-6 virus; rheumatic fever is caused by the bacterium, beta
    streptococcus, group A; Gillian-Barre syndrome may be caused by the bacterium,
    campylobacter; Crohn’s disease and ulcerative colitis by E. Coli, Klebsiella and
    Bacteroides; and so forth.

    Shouldn’t We Be Concerned About Resistant Bacteria?

    The argument that giving antibiotics causes bacteria to be resistant to that antibiotic
    is reasonable, but it has no place in discouraging people with these diseases from
    taking them. First, these people have serious diseases that cause permanent
    damage life and death. Second, the treatments that are available are toxic, shorten
    life, cause cancer, and have to be followed by frequent blood tests. On the other
    hand, I prescribe derivatives of tetracycline and erythromycin. These are
    extraordinarily safe and do not require drawing frequent blood tests.

    If you were to become infected subsequently with bacteria that are resistant to
    these antibiotics, you would have lost nothing. No reasonable doctor would prescribe
    erythromycin or tetracycline for acute serious diseases, such as meningitis,
    pneumonia, or an abscess, because tetracyclines and erythromycins do not kill
    germs, they only stop them from multiplying. Instead, doctors prescribe far more
    bacteriocidal antibiotics that kill bacteria.

    Many doctors criticize my use of antibiotics, but many antibiotics are far safer than
    conventional treatment, cost less, can be administered by a general practitioner, and
    often cure the condition, rather that just suppressing symptoms. I know that most
    physicians who develop these conditions will treat themselves with antibiotics
    because they know that conventional treatments with prednisone, chloroquine,
    azathioprine, and methotrexate are toxic and my treatments with erythromycins and
    tetracyclines are safe.

    The Hidden Epidemic—Mycoplasma, Chlamydia, and Ureaplasma

    Mycoplasma, chlamydia, and ureaplasma are the smallest of free-living organisms.
    They are unlike all other all other bacteria because they have no cell walls and
    therefore must live inside cells. They are unlike viruses because they can live in
    cultures outside of cells and can be killed by certain antibiotics. However, they cannot
    be killed by most antibiotics, as most antibiotics work by damaging a bacteria’s cell
    wall. They can be killed by antibiotics such as tetracyclines or erythromycins that do
    not act on a cell wall.

    If you feel sick and your doctor is unable to make a diagnosis because all laboratory
    tests and cultures fail to reveal a cause, you could be infected with one or more of
    these bacteria. The only way that you will be cured is for your doctor to suspect an
    infection with these germs and for you to take long-acting erythromycin or
    tetracyclines for several weeks, months or years. They are the most common cause
    of venereal diseases and are a common cause of muscle and joint pains, burning in
    the stomach, a chronic cough, and chronic fatigue. They can cause transverse
    myelitis (paralysis of the spine); gall stones; a chronic sore throat; red itchy eyes,
    pain on looking at light and blindness; arthritis; brain and nerve damage with
    symptoms of lack of coordination, headaches and passing out; spotting between
    periods or uterine infections; kidney stones; testicular pain; asthma; heart attacks;
    strokes; cerebral palsy; premature birth; high blood pressure; nasal polyps; stuffy
    nose in newborns; chronic fatigue; belly pain; muscle pain; confusion; passing out
    and death; coughing; bloody diarrhea; and anal itching and bleeding.

    Mycoplasma, chlamydia, and ureaplasma infections are extraordinary difficult to
    diagnose and treat. No dependable tests are available to most practicing physicians
    that will rule infections with these bacteria in or out, and most doctors will not
    prescribe antibiotics to patients unless they have results of a laboratory test that
    confirms a specific infection. If you feel sick and your doctor unable to make a
    diagnosis because all laboratory test and cultures fail to reveal a cause, you could be
    infected with mycoplasma, chlamydia, or ureaplasma and will be cured only by taking
    long-acting erythromycin or tetracyclines for many months.

    Usually the first symptoms from chlamydia, ureaplasma and mycoplasma are burning
    on urination, a feeling that you have to urinate all the time, terrible discomfort when
    the bladder is full and vaginal itching, odor or discharge. Other first symptoms include
    itchy eyes, a cough or a burning in your nose. The bacteria are transmitted through
    sexual contact, or you can be infected when an infected person coughs in your face
    or you touched nasal or eye secretions from an infected person and put your finger
    in your nose or eye. Your chances for a cure are high if you are treated when you
    have only local symptoms; but after many months the infection can spread to other
    parts of your body and make you sick or damage nerves, joints and muscles.

    Once these infections are allowed to persist for months or years, they are
    extraordinarily difficult to cure and often require treatment for many months. Even if
    your doctor is willing to prescribe antibiotics, treatment can be difficult. Often
    patients do not take the medication long enough to be cured, or they may have a
    close contact with an infected person and become reinfected. One patient in four
    takes of medication as prescribed and almost all women who had chlamydia one
    month after treatment had been reinfected by new or old partners.

    My recommended treatment: I often prescribe 500 mg of azithromycin twice a week
    and/or doxycycline 100-mg twice a day. Many physicians disagree with these
    recommendations, so check with your doctor to see if you may be a candidate for this
    treatment.

    Reactive and Rheumatoid Arthritis

    Most rheumatologist refuse to treat their rheumatoid arthritis patients with
    antibiotics even though all five controlled prospective studies conducted to date
    show that minocycline drops the rheumatoid factor towards zero and helps to
    alleviate the pain and destruction of cartilage of rheumatoid arthritis. There are two
    major types of arthritis: osteoarthritis, also called degenerative arthritis; and
    reactive arthritis, which includes rheumatoid arthritis. Osteoarthritis means that
    cartilage wears away and doctors don’t have the foggiest idea why. There is no
    effective treatment. Doctors usually prescribe non-steroidal pills that help to block
    pain but do not stop or even slow down the destruction of cartilage.

    Most scientists agree that an infection initiates rheumatoid and other reactive
    arthritides and most think that the germ is still there when the symptoms start.
    Short-term antibiotics are ineffective, but if antibiotics are started before the joint is
    destroyed, many months and years of antibiotics are effective in reducing and
    preventing joint damage. Your arthritis is likely to be classified as reactive arthritis if
    you have: 1) positive blood tests for arthritis (all tests used to diagnose arthritis are
    measures of an overactive immunity); 2) swelling of the knuckles and middle joints of
    your fingers, causing them to look like cigars; 3) a history of a long-standing infection
    such as a chronic cough, burning on urination or pain when the bladder is full, chronic
    diarrhea, burning in the stomach, throat or nose, or gum disease; and 4) symptoms
    that begin before age 50.

    Rheumatoid arthritis is characterized by pain in many muscles and joints and is
    thought to be caused by a person’s own antibodies and cells and cells attacking and
    destroying cartilage in joints. Rheumatoid arthritis may be triggered by infection and
    antibiotics may help to prevent and treat this joint destruction. Most rheumatologists
    treat rheumatoid arthritis with immune suppressants, which are extraordinarily
    expensive, highly toxic and, in my opinion, far less effective in controlling rheumatoid
    arthritis than antibiotics. Antibiotics are effective in controlling the symptoms of
    rheumatoid arthritis and higher doses are more effective. Short-term antibiotics are
    ineffective. Doxycycline may prevent joint destruction by stabilizing cartilage in
    addition to clearing the germ from the body.

    How do germs cause arthritis? When a germ gets into your body, you manufacture
    cells and proteins called antibodies that attach to and kill that germ. Sometimes, the
    germ has a surface protein that is similar to the surface protein in your cells. Then,
    not only do the antibodies attach to and kill the germ, they also attach to and kill
    your own cells that have the same surface membranes. People with rheumatoid
    arthritis have high antibody titer to E. Coli, a bacteria that lives normally in
    everyone’s intestines. It has the same surface protein as many cells in your body.
    Normal intestines do not permit E. Coli to get into your bloodstream.

    The people who get rheumatoid arthritis may be those whose intestines allow E. Coli
    to pass into the blood stream and cause the immune reaction that destroys muscles
    and joints. The same type of reaction applies to several other bacteria and viruses
    that can pass into your blood stream. Venereal diseases, such as gonorrhea,
    chlamydia, mycoplasma, and ureaplasma have been found in the joint fluid of many
    people with arthritis. People with rheumatoid arthritis are more likely to have staph
    aureus in their noses and carry higher antibody titer against that germ. Many people
    with rheumatoid arthritis have had chronic lung infections, caused by mycoplasma
    and chlamydia, prior to getting rheumatoid arthritis.

    I have seen antibiotics reduce high rheumatoid factors to zero, alleviate symptoms
    and stop the progressive destruction of cartilage in joints. The lead paper at a recent
    meeting of the American Academy of Rheumatology showed that Minocycline is the
    safest and least expensive drug that effectively stops progressive joint damage
    caused by rheumatoid arthritis. It is most effective when given before extensive
    cartilaginous damage occurs. I treat my reactive arthritis patients with Minocycline
    100 mg twice a day, (sometimes azithromycin 500-mg twice a week). This must still
    be considered experimental because most doctors are not yet ready to accept
    antibiotics as treatment. There is also concern about a rare, serious side effect of
    lupus. However, other papers show that even osteoarthritis may respond to
    antibiotics.

    Late-Onset Asthma May Be Caused by Infection

    A recent issue of the Journal of the American Medical Association reviews articles
    showing that asthma that starts after puberty can be caused by an infection. At the
    37th Interscience Conference on Antimicrobial Agents and Chemotherapy in Toronto,
    papers were presented showing that mycoplasma is a common cause of pneumonia
    in young adults and children, a common cause for meningitis, nerve damage, heart
    and muscle infection, (myocarditis) and arthritis, and a common cause of asthma in
    young adults. One paper showed that a significant number of young adults who
    develop asthma caused by mycoplasma fail to develop antibodies to kill that bacteria,
    so they continue to be infected for the rest of their lives. Another paper showed that
    another intracellular bacteria called ureaplasma is a common cause of asthma in
    young children. Since practicing physicians usually do not have an available
    laboratory test to find chlamydia, ureaplasma and mycoplasma, doctors should
    consider prescribing antibiotics for some people with persistent wheezing and
    coughing (azithromycin, clarithromysin, dirithromycin, minocycline or doxycycline).

    Fibromyalgia, Chronic Fatigue Syndrome or Multiple Chemical Sensitivities

    Fibromyalgia means that a previously healthy person develops unexplained
    exhaustion, fatigue and muscle aches and pains that last for more that six months;
    all blood tests are normal and doctors can’t find a cause. One recent report shows
    that a large number of people who were diagnosed with having fibromyalgia really
    had polymyalgia rheumatica, which does have abnormal blood tests. A recent report
    shows that many sufferers have low spinal fluid levels of vitamin B12 can be treated
    with 1000mcg of B12 each day. The diagnosis of fibromyalgia should be made only
    after all other causes have been ruled out. Many infections can cause fatigue and
    muscle pain.

    The evaluation should include tests for infectious diseases; such as Lyme disease
    and Hepatitis B or C, cytomegalovirus, toxoplasmosis or the helicobacter that causes
    stomach ulcers; autoimmune diseases, such as rheumatoid arthritis, lupus, Crohn’s
    disease or ulcerative colitis; hidden cancers such as those of the breast and
    prostate; hormonal diseases such as low thyroid; or side effects from a medication or
    illicit drug. Around 20 percent will be depressed. Most people miss work and complain
    of illness long before their diagnosis, but the majority will not have a known cause.

    Chronic fatigue means that the primary symptom is exhaustion, but most also have
    constipation and diarrhea. Fibromyalgia usually means that muscle and joint pains
    are major symptoms, but muscle biopsies are normal, pressure points are not
    reproducible and ultra sound is normal. Multiple chemical sensitivities mean that
    patients think that their symptoms are caused by factors in their environment or they
    consult doctors who think the same thing. Untreated, the symptoms that that lead to
    any of these diagnoses will usually continue in adults for the rest of their lives. I
    have prescribed doxycycline 100-mg twice a day for several months, and sometimes
    azithromycin 500-mg twice a week, and some of my patients get better. However,
    this treatment is not accepted by most doctors. Please check with your doctor.

    Ulcerative Colitis and Crohn’s Disease

    When a person has bloody diarrhea and doctors find ulcers in the intestines, they
    look for cancer, infection or parasites. When they can’t find a cause, they should say
    that they don’t have the foggiest idea why the person has intestinal ulcers. Instead,
    they deceive their patients by saying that the person has Chiron’s disease and
    explaining that the person’s immunity is so stupid that it punches holes in the
    intestines, rather than doing its job of killing germs. They prescribe medications that
    suppress immunity or cut out parts of intestine.

    Normal intestines are so loaded with bacteria that doctors can’t possibly tell which
    belong there and which may be causing disease. The conventional treatment offers
    no cure and is associated with many complications that shorten life. Exciting research
    from France show that a variant of E. Coli, a bacteria that lives in normal intestines,
    sticks to the intestinal lining and produces an alpha hemolytic that punches holes in
    the intestines to cause at least some cases of Crohn’s disease.

    Further studies show that heat shock protein can be removed from the common
    intestinal bacteria, E. Coli, and when given to mice, causes terrible bloody ulcers to
    form in the intestines. Under the microscope, intestines looked exactly the same as
    those of people who suffer from ulcerative colitis or Crohn’s disease. Extensive data
    show that people with this condition have leaky intestines that allow germs to pass
    into the bloodstream and their immunities are trying to kill these germs.

    Antibiotics can reduce swelling and ulcers in Crohn’s disease. Dr. Joel Taurog of the
    University of Texas has shown that a bacteria called bacteroides causes ulcerative
    colitis and Crohn’s disease in mice who are genetically programmed to have an
    HLA-B27, a special gene that causes arthritis. Special tissue staining techniques
    show that tissue taken from patients with Crohn’s disease and ulcerative colitis
    contain parts of two common bacteria called E. Coli and streptococci. Many studies
    show that infections may cause Crohn’s disease and that antibiotics, particularly
    Cipro with or without metronidazole, control ulcerative colitis and Crohn’s disease.
    Although many doctors disagree, I treat Crohn’s disease with Cipro 500-mg twice a
    day continuously and metronidazole 250-mg four times a day on alternate weeks
    and check liver tests monthly. I tell patients to stop the metronidazole if they feel
    any strange nerve sensations.

    Stomach Problems

    If you have belching, burping, a sour taste in your mouth, mouth odor, a
    white-coated tongue or a burning pain in your stomach or chest that gets worse
    when you are hungry and better when you eat, you probably have too much
    stomach acid. Doctors may say you have ulcers, esophagitis, gastritis, duodenitis,
    achalasia, chalazia, hiatal hernia or reflux. These terms mean that stomach acid is
    burning your gastrointestinal tract. Most people who have these symptoms have an
    infection with a bacteria called helicobacter pylori.

    If you have these symptoms, you need blood tests to see if you have helicobacter
    and a special x-ray called an upper GI series to rule out a cancer. Since there are
    several bacteria that cause stomach cancers ulcers, a negative blood test does not
    rule out an infection. I usually treat all people with gastritis symptoms with a
    one-week course of antibiotics: metronidazole four times a day, clarithromycin
    500-mg twice a day and omeperazole 20-mg once a day for one week. At least 12
    weeks later, you need a follow up blood test for helicobacter.

    If your symptoms are gone and the titer drops, you are probably cured. If your
    helicobacter titer is still high, your helicobacter is probably resistant to metronidazole
    and your need to be treated for at least ten days with amoxicillin 500-mg four times
    a day, tetracycline 500-mg three times a day and omeperazole 20-mg once a day. If
    you have regurgitation of stomach acid into your esophagus (reflux, hiatal hernia),
    you may need to be treated with 20-mg omeperazole once a day and 10-mg
    cisapride four times a day. Virtually all physicians have now accepted the infectious
    causes of stomach problems. Only the manufacturers of over-the-counter remedies
    still try to make you believe that stomach pain is caused by stress.

    Doxycycline, Minocycline and Tetracycline

    Many doctors have asked why I treat some of my patients with acne, arthritis,
    chronic fatigue syndrome, and late on-set asthma with antibiotic, doxycycline, when
    minocycline is probably more effective. Doxycycline is a fairly safe drug, although it
    can cause a sore throat, sunlight sensitivity, pigmentation and abnormal liver tests.
    It causes sore throat and heartburn when it gets stuck in your esophagus, so take it
    with large amounts of water to wash it down to your stomach. To prevent sunburn,
    avoid excessive exposure to the sun. Minocycline is fairly safe, but it can cause more
    serious serum sickness-like reaction, hypersensitivity syndrome reaction, and
    drug-induced lupus: characterized by fever, joint pain, a rash, a feeling of being sick,
    hives itching and severe pain. Other reported side effects include dark colored
    eyeballs, and liver damage.

    Minocycline is more effective than doxycycline because it achieves much higher
    concentrations in the tissues where it does work in reducing swelling, killing germs,
    and stopping pain. Although minocycline and doxycycline are in the same class of
    antibiotics as tetracycline, we rarely use tetracycline because it does not achieve
    high tissue concentrations. Doxycycline achieves much higher tissue concentrations
    than tetracycline, while minocycline penetrates tissue far more effectively than
    doxycycline.

  2. Rozmund

    Rozmund New Member


    Why I Prescribe Antibiotics to Patients with Chronic Fatigue Syndrome, Fibromyalgia,
    Multiple Chemical Sensitivity, and Other Autoimmune Diseases

    Part of email newsletter I received from ProHealth today.
    11-20-2002

    By Gabe Mirkin M.D.

    Before I prescribe any medication, I ask myself whether it will help or hurt. All of the
    autoimmune diseases cause severe disability. Conventional medications neither cure
    these diseases nor stop the progressive destruction that they cause. Doctors
    prescribe immune suppressives that sometimes have deadly effects. Antibiotics are
    far safer that the drugs conventionally used to treat these diseases. So, if antibiotics
    can be shown to help control these diseases, they should be used long before a
    doctor thinks of using the conventional immune suppressives.

    When a germ gets into your body, you are supposed to produce cells and proteins
    called antibodies that attach to and kill that germ. These diseases are felt by many
    doctors to be caused by your own immunity. Instead of doing its job of killing germs,
    your immunity attacks your own tissue. If it attacks your joints, it's called reactive
    arthritis; if it attacks your intestines, it’s called Crohn’s disease; your colon, it’s called
    ultra ulcerative colitis; and if it fills your lungs with mucous, it’s called late onset
    asthma. I do not believe that your immunity is that stupid.

    Accumulating data show that all of these conditions can be caused by infection. Many
    diseases that were thought to be autoimmune turn out to be infections: stomach
    ulcers are caused by bacterium, helicobacter pylori and others; multiple sclerosis may
    be caused by HHS-6 virus; rheumatic fever is caused by the bacterium, beta
    streptococcus, group A; Gillian-Barre syndrome may be caused by the bacterium,
    campylobacter; Crohn’s disease and ulcerative colitis by E. Coli, Klebsiella and
    Bacteroides; and so forth.

    Shouldn’t We Be Concerned About Resistant Bacteria?

    The argument that giving antibiotics causes bacteria to be resistant to that antibiotic
    is reasonable, but it has no place in discouraging people with these diseases from
    taking them. First, these people have serious diseases that cause permanent
    damage life and death. Second, the treatments that are available are toxic, shorten
    life, cause cancer, and have to be followed by frequent blood tests. On the other
    hand, I prescribe derivatives of tetracycline and erythromycin. These are
    extraordinarily safe and do not require drawing frequent blood tests.

    If you were to become infected subsequently with bacteria that are resistant to
    these antibiotics, you would have lost nothing. No reasonable doctor would prescribe
    erythromycin or tetracycline for acute serious diseases, such as meningitis,
    pneumonia, or an abscess, because tetracyclines and erythromycins do not kill
    germs, they only stop them from multiplying. Instead, doctors prescribe far more
    bacteriocidal antibiotics that kill bacteria.

    Many doctors criticize my use of antibiotics, but many antibiotics are far safer than
    conventional treatment, cost less, can be administered by a general practitioner, and
    often cure the condition, rather that just suppressing symptoms. I know that most
    physicians who develop these conditions will treat themselves with antibiotics
    because they know that conventional treatments with prednisone, chloroquine,
    azathioprine, and methotrexate are toxic and my treatments with erythromycins and
    tetracyclines are safe.

    The Hidden Epidemic—Mycoplasma, Chlamydia, and Ureaplasma

    Mycoplasma, chlamydia, and ureaplasma are the smallest of free-living organisms.
    They are unlike all other all other bacteria because they have no cell walls and
    therefore must live inside cells. They are unlike viruses because they can live in
    cultures outside of cells and can be killed by certain antibiotics. However, they cannot
    be killed by most antibiotics, as most antibiotics work by damaging a bacteria’s cell
    wall. They can be killed by antibiotics such as tetracyclines or erythromycins that do
    not act on a cell wall.

    If you feel sick and your doctor is unable to make a diagnosis because all laboratory
    tests and cultures fail to reveal a cause, you could be infected with one or more of
    these bacteria. The only way that you will be cured is for your doctor to suspect an
    infection with these germs and for you to take long-acting erythromycin or
    tetracyclines for several weeks, months or years. They are the most common cause
    of venereal diseases and are a common cause of muscle and joint pains, burning in
    the stomach, a chronic cough, and chronic fatigue. They can cause transverse
    myelitis (paralysis of the spine); gall stones; a chronic sore throat; red itchy eyes,
    pain on looking at light and blindness; arthritis; brain and nerve damage with
    symptoms of lack of coordination, headaches and passing out; spotting between
    periods or uterine infections; kidney stones; testicular pain; asthma; heart attacks;
    strokes; cerebral palsy; premature birth; high blood pressure; nasal polyps; stuffy
    nose in newborns; chronic fatigue; belly pain; muscle pain; confusion; passing out
    and death; coughing; bloody diarrhea; and anal itching and bleeding.

    Mycoplasma, chlamydia, and ureaplasma infections are extraordinary difficult to
    diagnose and treat. No dependable tests are available to most practicing physicians
    that will rule infections with these bacteria in or out, and most doctors will not
    prescribe antibiotics to patients unless they have results of a laboratory test that
    confirms a specific infection. If you feel sick and your doctor unable to make a
    diagnosis because all laboratory test and cultures fail to reveal a cause, you could be
    infected with mycoplasma, chlamydia, or ureaplasma and will be cured only by taking
    long-acting erythromycin or tetracyclines for many months.

    Usually the first symptoms from chlamydia, ureaplasma and mycoplasma are burning
    on urination, a feeling that you have to urinate all the time, terrible discomfort when
    the bladder is full and vaginal itching, odor or discharge. Other first symptoms include
    itchy eyes, a cough or a burning in your nose. The bacteria are transmitted through
    sexual contact, or you can be infected when an infected person coughs in your face
    or you touched nasal or eye secretions from an infected person and put your finger
    in your nose or eye. Your chances for a cure are high if you are treated when you
    have only local symptoms; but after many months the infection can spread to other
    parts of your body and make you sick or damage nerves, joints and muscles.

    Once these infections are allowed to persist for months or years, they are
    extraordinarily difficult to cure and often require treatment for many months. Even if
    your doctor is willing to prescribe antibiotics, treatment can be difficult. Often
    patients do not take the medication long enough to be cured, or they may have a
    close contact with an infected person and become reinfected. One patient in four
    takes of medication as prescribed and almost all women who had chlamydia one
    month after treatment had been reinfected by new or old partners.

    My recommended treatment: I often prescribe 500 mg of azithromycin twice a week
    and/or doxycycline 100-mg twice a day. Many physicians disagree with these
    recommendations, so check with your doctor to see if you may be a candidate for this
    treatment.

    Reactive and Rheumatoid Arthritis

    Most rheumatologist refuse to treat their rheumatoid arthritis patients with
    antibiotics even though all five controlled prospective studies conducted to date
    show that minocycline drops the rheumatoid factor towards zero and helps to
    alleviate the pain and destruction of cartilage of rheumatoid arthritis. There are two
    major types of arthritis: osteoarthritis, also called degenerative arthritis; and
    reactive arthritis, which includes rheumatoid arthritis. Osteoarthritis means that
    cartilage wears away and doctors don’t have the foggiest idea why. There is no
    effective treatment. Doctors usually prescribe non-steroidal pills that help to block
    pain but do not stop or even slow down the destruction of cartilage.

    Most scientists agree that an infection initiates rheumatoid and other reactive
    arthritides and most think that the germ is still there when the symptoms start.
    Short-term antibiotics are ineffective, but if antibiotics are started before the joint is
    destroyed, many months and years of antibiotics are effective in reducing and
    preventing joint damage. Your arthritis is likely to be classified as reactive arthritis if
    you have: 1) positive blood tests for arthritis (all tests used to diagnose arthritis are
    measures of an overactive immunity); 2) swelling of the knuckles and middle joints of
    your fingers, causing them to look like cigars; 3) a history of a long-standing infection
    such as a chronic cough, burning on urination or pain when the bladder is full, chronic
    diarrhea, burning in the stomach, throat or nose, or gum disease; and 4) symptoms
    that begin before age 50.

    Rheumatoid arthritis is characterized by pain in many muscles and joints and is
    thought to be caused by a person’s own antibodies and cells and cells attacking and
    destroying cartilage in joints. Rheumatoid arthritis may be triggered by infection and
    antibiotics may help to prevent and treat this joint destruction. Most rheumatologists
    treat rheumatoid arthritis with immune suppressants, which are extraordinarily
    expensive, highly toxic and, in my opinion, far less effective in controlling rheumatoid
    arthritis than antibiotics. Antibiotics are effective in controlling the symptoms of
    rheumatoid arthritis and higher doses are more effective. Short-term antibiotics are
    ineffective. Doxycycline may prevent joint destruction by stabilizing cartilage in
    addition to clearing the germ from the body.

    How do germs cause arthritis? When a germ gets into your body, you manufacture
    cells and proteins called antibodies that attach to and kill that germ. Sometimes, the
    germ has a surface protein that is similar to the surface protein in your cells. Then,
    not only do the antibodies attach to and kill the germ, they also attach to and kill
    your own cells that have the same surface membranes. People with rheumatoid
    arthritis have high antibody titer to E. Coli, a bacteria that lives normally in
    everyone’s intestines. It has the same surface protein as many cells in your body.
    Normal intestines do not permit E. Coli to get into your bloodstream.

    The people who get rheumatoid arthritis may be those whose intestines allow E. Coli
    to pass into the blood stream and cause the immune reaction that destroys muscles
    and joints. The same type of reaction applies to several other bacteria and viruses
    that can pass into your blood stream. Venereal diseases, such as gonorrhea,
    chlamydia, mycoplasma, and ureaplasma have been found in the joint fluid of many
    people with arthritis. People with rheumatoid arthritis are more likely to have staph
    aureus in their noses and carry higher antibody titer against that germ. Many people
    with rheumatoid arthritis have had chronic lung infections, caused by mycoplasma
    and chlamydia, prior to getting rheumatoid arthritis.

    I have seen antibiotics reduce high rheumatoid factors to zero, alleviate symptoms
    and stop the progressive destruction of cartilage in joints. The lead paper at a recent
    meeting of the American Academy of Rheumatology showed that Minocycline is the
    safest and least expensive drug that effectively stops progressive joint damage
    caused by rheumatoid arthritis. It is most effective when given before extensive
    cartilaginous damage occurs. I treat my reactive arthritis patients with Minocycline
    100 mg twice a day, (sometimes azithromycin 500-mg twice a week). This must still
    be considered experimental because most doctors are not yet ready to accept
    antibiotics as treatment. There is also concern about a rare, serious side effect of
    lupus. However, other papers show that even osteoarthritis may respond to
    antibiotics.

    Late-Onset Asthma May Be Caused by Infection

    A recent issue of the Journal of the American Medical Association reviews articles
    showing that asthma that starts after puberty can be caused by an infection. At the
    37th Interscience Conference on Antimicrobial Agents and Chemotherapy in Toronto,
    papers were presented showing that mycoplasma is a common cause of pneumonia
    in young adults and children, a common cause for meningitis, nerve damage, heart
    and muscle infection, (myocarditis) and arthritis, and a common cause of asthma in
    young adults. One paper showed that a significant number of young adults who
    develop asthma caused by mycoplasma fail to develop antibodies to kill that bacteria,
    so they continue to be infected for the rest of their lives. Another paper showed that
    another intracellular bacteria called ureaplasma is a common cause of asthma in
    young children. Since practicing physicians usually do not have an available
    laboratory test to find chlamydia, ureaplasma and mycoplasma, doctors should
    consider prescribing antibiotics for some people with persistent wheezing and
    coughing (azithromycin, clarithromysin, dirithromycin, minocycline or doxycycline).

    Fibromyalgia, Chronic Fatigue Syndrome or Multiple Chemical Sensitivities

    Fibromyalgia means that a previously healthy person develops unexplained
    exhaustion, fatigue and muscle aches and pains that last for more that six months;
    all blood tests are normal and doctors can’t find a cause. One recent report shows
    that a large number of people who were diagnosed with having fibromyalgia really
    had polymyalgia rheumatica, which does have abnormal blood tests. A recent report
    shows that many sufferers have low spinal fluid levels of vitamin B12 can be treated
    with 1000mcg of B12 each day. The diagnosis of fibromyalgia should be made only
    after all other causes have been ruled out. Many infections can cause fatigue and
    muscle pain.

    The evaluation should include tests for infectious diseases; such as Lyme disease
    and Hepatitis B or C, cytomegalovirus, toxoplasmosis or the helicobacter that causes
    stomach ulcers; autoimmune diseases, such as rheumatoid arthritis, lupus, Crohn’s
    disease or ulcerative colitis; hidden cancers such as those of the breast and
    prostate; hormonal diseases such as low thyroid; or side effects from a medication or
    illicit drug. Around 20 percent will be depressed. Most people miss work and complain
    of illness long before their diagnosis, but the majority will not have a known cause.

    Chronic fatigue means that the primary symptom is exhaustion, but most also have
    constipation and diarrhea. Fibromyalgia usually means that muscle and joint pains
    are major symptoms, but muscle biopsies are normal, pressure points are not
    reproducible and ultra sound is normal. Multiple chemical sensitivities mean that
    patients think that their symptoms are caused by factors in their environment or they
    consult doctors who think the same thing. Untreated, the symptoms that that lead to
    any of these diagnoses will usually continue in adults for the rest of their lives. I
    have prescribed doxycycline 100-mg twice a day for several months, and sometimes
    azithromycin 500-mg twice a week, and some of my patients get better. However,
    this treatment is not accepted by most doctors. Please check with your doctor.

    Ulcerative Colitis and Crohn’s Disease

    When a person has bloody diarrhea and doctors find ulcers in the intestines, they
    look for cancer, infection or parasites. When they can’t find a cause, they should say
    that they don’t have the foggiest idea why the person has intestinal ulcers. Instead,
    they deceive their patients by saying that the person has Chiron’s disease and
    explaining that the person’s immunity is so stupid that it punches holes in the
    intestines, rather than doing its job of killing germs. They prescribe medications that
    suppress immunity or cut out parts of intestine.

    Normal intestines are so loaded with bacteria that doctors can’t possibly tell which
    belong there and which may be causing disease. The conventional treatment offers
    no cure and is associated with many complications that shorten life. Exciting research
    from France show that a variant of E. Coli, a bacteria that lives in normal intestines,
    sticks to the intestinal lining and produces an alpha hemolytic that punches holes in
    the intestines to cause at least some cases of Crohn’s disease.

    Further studies show that heat shock protein can be removed from the common
    intestinal bacteria, E. Coli, and when given to mice, causes terrible bloody ulcers to
    form in the intestines. Under the microscope, intestines looked exactly the same as
    those of people who suffer from ulcerative colitis or Crohn’s disease. Extensive data
    show that people with this condition have leaky intestines that allow germs to pass
    into the bloodstream and their immunities are trying to kill these germs.

    Antibiotics can reduce swelling and ulcers in Crohn’s disease. Dr. Joel Taurog of the
    University of Texas has shown that a bacteria called bacteroides causes ulcerative
    colitis and Crohn’s disease in mice who are genetically programmed to have an
    HLA-B27, a special gene that causes arthritis. Special tissue staining techniques
    show that tissue taken from patients with Crohn’s disease and ulcerative colitis
    contain parts of two common bacteria called E. Coli and streptococci. Many studies
    show that infections may cause Crohn’s disease and that antibiotics, particularly
    Cipro with or without metronidazole, control ulcerative colitis and Crohn’s disease.
    Although many doctors disagree, I treat Crohn’s disease with Cipro 500-mg twice a
    day continuously and metronidazole 250-mg four times a day on alternate weeks
    and check liver tests monthly. I tell patients to stop the metronidazole if they feel
    any strange nerve sensations.

    Stomach Problems

    If you have belching, burping, a sour taste in your mouth, mouth odor, a
    white-coated tongue or a burning pain in your stomach or chest that gets worse
    when you are hungry and better when you eat, you probably have too much
    stomach acid. Doctors may say you have ulcers, esophagitis, gastritis, duodenitis,
    achalasia, chalazia, hiatal hernia or reflux. These terms mean that stomach acid is
    burning your gastrointestinal tract. Most people who have these symptoms have an
    infection with a bacteria called helicobacter pylori.

    If you have these symptoms, you need blood tests to see if you have helicobacter
    and a special x-ray called an upper GI series to rule out a cancer. Since there are
    several bacteria that cause stomach cancers ulcers, a negative blood test does not
    rule out an infection. I usually treat all people with gastritis symptoms with a
    one-week course of antibiotics: metronidazole four times a day, clarithromycin
    500-mg twice a day and omeperazole 20-mg once a day for one week. At least 12
    weeks later, you need a follow up blood test for helicobacter.

    If your symptoms are gone and the titer drops, you are probably cured. If your
    helicobacter titer is still high, your helicobacter is probably resistant to metronidazole
    and your need to be treated for at least ten days with amoxicillin 500-mg four times
    a day, tetracycline 500-mg three times a day and omeperazole 20-mg once a day. If
    you have regurgitation of stomach acid into your esophagus (reflux, hiatal hernia),
    you may need to be treated with 20-mg omeperazole once a day and 10-mg
    cisapride four times a day. Virtually all physicians have now accepted the infectious
    causes of stomach problems. Only the manufacturers of over-the-counter remedies
    still try to make you believe that stomach pain is caused by stress.

    Doxycycline, Minocycline and Tetracycline

    Many doctors have asked why I treat some of my patients with acne, arthritis,
    chronic fatigue syndrome, and late on-set asthma with antibiotic, doxycycline, when
    minocycline is probably more effective. Doxycycline is a fairly safe drug, although it
    can cause a sore throat, sunlight sensitivity, pigmentation and abnormal liver tests.
    It causes sore throat and heartburn when it gets stuck in your esophagus, so take it
    with large amounts of water to wash it down to your stomach. To prevent sunburn,
    avoid excessive exposure to the sun. Minocycline is fairly safe, but it can cause more
    serious serum sickness-like reaction, hypersensitivity syndrome reaction, and
    drug-induced lupus: characterized by fever, joint pain, a rash, a feeling of being sick,
    hives itching and severe pain. Other reported side effects include dark colored
    eyeballs, and liver damage.

    Minocycline is more effective than doxycycline because it achieves much higher
    concentrations in the tissues where it does work in reducing swelling, killing germs,
    and stopping pain. Although minocycline and doxycycline are in the same class of
    antibiotics as tetracycline, we rarely use tetracycline because it does not achieve
    high tissue concentrations. Doxycycline achieves much higher tissue concentrations
    than tetracycline, while minocycline penetrates tissue far more effectively than
    doxycycline.

  3. Rozmund

    Rozmund New Member

    Can you share your regime with us - I have heard of all of these things - but in Canada we do not
    have access to the silver - or the oregano oil. But when we had an ecoli breakout in Walkerton Ontario
    that took 7 lives and made 2300 people deathly sick leaving some with kidneys that will be permanently
    damaged - 1000 courses of oregano oil were donated by Dr. Imgram I believe - I understand it is quite
    costly. Even your sources would be of immense help to many. Cheers
  4. tedebear

    tedebear New Member

    I am allergic to Doxy. Severe rash and vomiting. They no longer administer to me, but I have found that Z-pack works best. I have built up an immunity to other antibiotics. System goes through cycles. One year a certain antibiotic works, the next year it is ineffective. Can't explain why. Know one seems to know why. I had H-Pylori 2 yrs. ago. Get repeated infections througout the year. I will mention this to GP when I get my next appt.
    Very informative info here. A must read.
    Soft hugs and thanks.
  5. Rozmund

    Rozmund New Member

    Thanks for such a swift response. I got up this morning at 5:30 AM EST and my inbox was alive so I just thought I would share the good news. Yes, I am allergic also to a few antiobotics but I did tolerate the doxy and erthomycin pack quite well - however, my doc would only medicate me for 3 months - he was unfamiliar with FMS and the whole ball of wax But it was the best 3 months I have had in a long time. Unless they are specializing in autoimmune diseases they are really in the dark on alot. That is why going to a specialist is the best. I now email, fax or mail information to mine - and the poor guy is so busy that sometimes he only reads it while I am in his office. Re Pylori- there are now 19 variations on this - if you tested for one you may have more - I know this sounds yucky - but either soak your toothbrush in a disinfectant - or buy a new every few weeks. Another thing, never ever share a glass or straw with anyone - that is how it spreads, and if you are married, your spouse should be checked as well. My daughter got it and constantly got reinfected only to finally find out her hubby had it. If you can tolerate acidophillus that is a good bacteria and when taking any antibiotics this should be taken as well - make sure when you get it that it is "live" from the refrigerator of the health food store or drugstore. I will be making another post soon on Vitamin A and its apparent depletion for us folks. Nice to have met you....do you post often? Cheers
  6. Mikie

    Mikie Moderator

    And have been for about a year now. I improve while on it and get sick every time I try to cycle off of it withing three days of stopping the drug. My onset was triggered 12 years ago by a mycoplasma infection, just at the start of the Gulf War. I live next to a military installation.

    BTW, Dr. Garth Nicolson, the father of mycoplasma research, says his tests indicate that between 60 and 70 percent of people with CFS/FMS have chronic mycoplasma infections.

    The author of this article evidently did not know that there are lab tests for these infections. They are PCR DNA tests which are done by only a handful of labs in the U.S. They are expensive, the blood must be carefully handled, and there is a high probability of a false neg. I think the author of this article is right to try the antibiotics without relying on the tests becuase if you do not have a chronic bacterial infection, the antibiotics will do nothing.

    For anyone who has improved on antibiotics but whose doc will not continue to prescribe them, do some research on mycoplasmas. Dr. Nicolson says it can take several years on the antibiotics to get rid of the mycoplasmas. I will try to cycle off again in Jan. if I am feeling well.

    Love, Mikie
  7. Rozmund

    Rozmund New Member

    Being new on the board - I get the impression that Doxy treatment is not well known. Could you do a separate post and cut and past your response to me into it - I feel should spread the word - also being a moderator you already know along with many that when it comes to questions - the search feature on the site is fantastic. I wonder if alot of the newbie know this - this would in no way dimish contact - but in the wee hours when you are plagued with that stranded feeling - just looking up what others have said on a certain issue can be reassuring even it is during the last year. What say you gal? Cheers
  8. Mikie

    Mikie Moderator

    Will do, but most here do know about my treatment for the mycoplasmas.

    Love, Mikie

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