Antidepressant Use Not Linked to Birth Defects

Discussion in 'Fibromyalgia Main Forum' started by allhart, Apr 24, 2003.

  1. allhart

    allhart New Member

    i know alot of us worrie about having babies and the meds we take and have taken i found this and wanted to share it for you who are thinking of having a baby





    Antidepressant Use Not Linked to Birth Defects

    Pregnant women who take selective serotonin reuptake inhibitors (SSRIs), the class of antidepressants that includes Prozac, Paxil and Zoloft, appear to be no more likely to have a baby with birth defects than other women, according to a study by California scientists.

    "This study found no evidence that SSRI antidepressants used during pregnancy increase the risk of congenital malformations, low birth weight or preterm labor," said the study's lead author Dr. Victoria Hendrick of the University of California in Los Angeles.

    "These findings extend previous studies that have similarly reported no association between prenatal use of SSRIs and congenital malformations or low birth weight,"

    Further, although some research has suggested that SSRI antidepressants might increase the risk for early labor, "we did not find an elevated risk of preterm labor," Hendrick adds.

    In their study, Hendrick's team evaluated the birth outcomes of 138 healthy non-smoking pregnant women between the ages of 24 and 44. All of the women began prenatal care early in their pregnancy, the authors report in the American Journal of Obstetrics and Gynecology.

    Eighty-five women took an SSRI throughout their entire pregnancy, while the remaining women started the medication sometime during their pregnancy. SSRI medications taken by the women included Paxil (paroxetine), Prozac (fluoxetine) Zoloft (sertraline) and Luvox (fluvoxamine), the study indicates.

    Overall, the rate of major birth defects was 1.4 percent, similar to that seen in the general population, according to the report.

    The drugs were also not associated with an increased risk for low birth weight or preterm babies, but three women taking relatively high doses of Prozac -- 40 or 80 milligrams -- had low birthweight babies.

    However, this may have been due to their depression and not necessarily the drug, according to the report. Depressed women may eat less during pregnancy and thus gain less weight, putting their baby at risk for low birth weight. However, the researchers did not find any difference in weight gain in those women taking high doses of Prozac and other study participants.

    "Given the small number of low birth weight infants in this study, these findings should be considered preliminary," Hendrick's team write.

    "We tell pregnant women that the available data are mostly reassuring but certain reports remain to be explored further -- such as reports describing an increase in perinatal complications in newborns like jitteriness and (rapid breathing) ... and reports of a possible increase in the risk of preterm birth," said Hendrick.

    "Therefore we recommend that pregnant women try to minimize the use of antidepressants whenever possible, and that they maximize the use of nonpharmacologic options (such as) psychotherapy, couples counseling, or group support," concluded Hendrick. The study was funded by grants from the National Institute of Mental Health, the National Centers for Research Resources at the National Institutes of Health and the National Institute of Child Health and Human Development.

    SOURCE: American Journal of Obstetrics and Gynecology 2003;188:812-815


  2. allhart

    allhart New Member

    bumping agin
  3. Mikie

    Mikie Moderator

    We know that withdrawal from some of these meds can be horrible. I wonder whether they cross the placenta barrier and are in the baby's system. If so, do the babies go through withdrawal after birth?

    Love, Mikie
  4. allhart

    allhart New Member

    thats a grate?im not totally sure but sense i posted this ill check into it more,its horrible for adults ,i cant imagine a poor little babie going threw withdraws from the stuff,
  5. Mikie

    Mikie Moderator

    I'm sure this would be a wonderful service to our members.

    Love, Mikie
  6. allhart

    allhart New Member

    When some people stop taking paroxetine, they experience a "discontinuation" syndrome, which is a type of withdrawal from the drug. Recently, there have been several reports of irritability, jitteriness, excessive crying, shivering and other symptoms in newborns whose mothers took paroxetine during pregnancy, the authors note in their report in the November issue of the Archives of Pediatrics and Adolescent Medicine.

    after reading this i would say yes aleast paxil causes withdraws in infants,ill try and find the others mention


    zoloft,didnt find anything about withdraws in newborns but infants who where breastfeed by moms that took zoloft during breastfeeding showed signs of with draws for 24 to 48 hrs after they discontuied nursing,[This Message was Edited on 04/29/2003]