My high cholesterol is genetic . Just can't seem to get the numbers down no matter what I do. My diet is high fiber,very low fat , lots of veggies and fruit and almost no sugar,very ,very rarely drink wine ( heck I'm no angel =) ) . I've take vytorin for over a year and a half and it worked at first . My levels started at 350 and went down to around 279 and now it s back up to 302. So this doctor wants to try me on crestor. Now with my history of RA,copd,spondy,ect....... I am very concerned about muscle weakness getting worse. I've already taking so many pain for multiple diseases that one more pill may send me to the edge and back. I feel like a domestic drug lord . lol Anyways is there anyone here that has tried crestor ? I need advise . Chase are that I'll have to try it anyways but I'm still a worry wort about trying new stuff.