Anybody else feel like your nerves are shot or on edge?

Discussion in 'Fibromyalgia Main Forum' started by kriket, Sep 28, 2006.

  1. kriket

    kriket New Member

    Geeeez!!!! I am having one of those days where my nerves are so shaky. Everything is getting on my nerves. My b/f is an auto mechanic and his house is like grand central station, someone is always knocking on the door. He has too many dogs, and they are all just getting on my last nerve. I feel like I need a VACATION!!!!! Anybody else feel like you just can't get away from people and everything is getting on your last nerve?!!!!

  2. jake123

    jake123 New Member

    I have a classroom full of kids "gone wrong" as in going to school high, selling drugs at school, assault, fighting, and whatever.
    Today was so crappy because of one boy who made noises when I walked around the room and said under his breath 'she has a hunchback' (I have scoliosis'). Then he would stifle his laughing and get someone else to laugh. What a miserable kid.
    I did call the parents but did not get anyone. So I will do the 6:45 call. (So they can gripe at him all the way to school).
    I know what you mean Kricket about too much activity. It wears a person out. I get that way with my grandkids. My husband has to take them to so many activities because their mom won't. When they are here all they do is argue and fight with each other. I have to go to the back bedroom and hide or leave and go to the store. They are lovable though.
  3. Slayadragon

    Slayadragon New Member

    Yes, for the last few days. I don't know why.
  4. hermitlady

    hermitlady Member

    I'm ultra sensitive to loud noise, TV, stereo, kids, whatever. Makes me want to scream!!! Also bright lights are too much for me to me a headache.
    I think we all get anxiety just from feeling so sick all the time. I know I do.

    Get yourself some earplugs and go off in a room by yourself. Earplugs are the greatest discovery for me, can't sleep without them cuz I'm so sensitive to sounds. I use the soft silicone type, they work the best and are most comfortable.

    Good luck.....Hermit
  5. Scapper

    Scapper New Member

    YES.....all the time!
  6. sorekitty

    sorekitty New Member

    I have had a most difficult week. It is constant anxiety to the extreme and I have to remember to breathe.

    I'm so exhausted from it that today at my dr appointment I asked if he could clear off the exam table so I could lay down (lol) I had to lay down the whole appointment (my doc spends a lot of time with each patient).

    This week I was talking in a mean voice to my dh and realized I was doing it so that I wouldn't cry! I apologized to him when I figured it out.

    My little boy may have autism (Asperger's) but I have to wait for about 2 years before we know for sure. The waiting is killing me. I have been having to be in advocate mode for his preschool IEP. Plus, his extreme energy level and difficult behavior make me want to pull my hair out. But so many other times he is so sweet, loving and he is so handsome. Dr increased my xanax. We'll see. I think I just hijacked your post! Sorry guess I needed to vent.

  7. kriket

    kriket New Member

    I know I'm not the only one under stress with their nerves on edge. The keybord might blow its fuses on this one. Maybe we can all just support each other and listen. Whoever mentioned our nerves being extra sensitive from being so tired and in more pain than usual is right on. Completely makes since.

  8. boltchik

    boltchik New Member

    Sorry you are having a bad day!! When I am feeling like that I don't want anyone to knock on the door, and I don't feel like answering the phone. Most of my friends/family don't know that I am this sick, so sometimes I hope I don't come off as anti-social. Believe me, I want to be out there doing fun things everyday. I have 3 kids, so I try very hard to be very aware of my patience level. I don't want them to have to suffer the effects of this DD. Well, we have what we have, and I just try to be positive and deal with it. So, I am sending positive thoughts your way! Take care, Kim :)
  9. Redwillow

    Redwillow New Member

    Hi Kriket

    I feel like my nerves are exposed all the time and it doesn't take much to aggrevate them.

    I can't handle a lot of noise, music, people, bright lights. I live in the country and don't even have a radio on all day.

    Thank goodness my children aren't little anymore.

    hugs Redwillow
  10. msbad66

    msbad66 New Member

    I have forgotten what it feels like to relax. My nerves stay on edge all the time. Thanks to xanex(sp), I don't explode as often on my family. If I didn't feel wired and stressed now I'd think something was real wrong.

    God Bless All.....
  11. Mikie

    Mikie Moderator

    Of the slight seizure state Dr. Cheney describes in his article on Klonopin. Other symptoms are sensory overload, tinnitus, muscle spasms, and RLS. I had horrible anxiety and panic attacks as well as sensory overload. I could not go into Wal-Mart or noisy restaurants. The movement of the traffic when driving drove me crazy.

    I'll go get his article.

    Love, Mikie


    Dr. Paul Cheney Discusses the Benefits of Klonopin
    by Carol Sieverling


    Editor’s Note: The following is based on a recent interview conducted by Carol Sieverling with Dr. Paul R. Cheney, M.D., Ph.D., and the article "CFIDS Treatment: The Cheney Clinic’s Strategic Approach" (CFIDS Chronicle, Spring 1995). Dr. Cheney gave permission to share this information, but has not reviewed or edited it.

    Many CFIDS specialists prescribe the drug Klonopin. In the October 1999 issue of The Fibromyalgia Network, nine CFS/FM specialists summarized their most effective treatments, and six included Klonopin. Interestingly, the three who did not are primarily FM specialists.

    Dr. Cheney prescribes Klonopin to address a condition associated with CFIDS called "excitatory neurotoxicity." To explain this condition to patients, he draws a line with "seizure" on the far left and "coma" on the far right. A big dot in the middle represents where healthy people are when awake. A dot somewhat to the right of the middle indicates where healthy people are when asleep – slightly shifted toward coma. He highlights in red the left portion of the line, from seizure to the middle, and labels it "Neurotoxic State" (damaging to the brain). He highlights in blue the right portion of the line, from coma to the middle, and labels it "Healing State."

    In CFIDS, an ongoing injury to the brain shifts patients toward seizure. A dot to the left of the middle, marked "injury," represents the position of CFIDS patients. This puts us in the red "Neurotoxic" zone. When we shift toward seizure, we often experience "sensory overload." It’s as if our brain’s "radar" is too sensitive. Our neurons (nerve cells) are sensing stimuli and firing when they should not. This causes amplification of sensory input. Light, noise, motion and pain are all magnified. At the beginning of their illness, many patients report feeling exhausted, yet also strangely "wired." The "wired" feeling is the slight shift towards seizure that occurs as a result of the excitatory neurotoxicity.

    Cheney frequently uses the term "threshold potential" when discussing excitatory neurotoxicity. (Think of the threshold - bottom - of a doorway. The lower it is, the more accessible it is. When it is at floor level, everything can enter. When it is raised, access is restricted to taller people. If it is too high, no one can enter.) Threshold potential refers to how much stimulus it takes to make neurons fire. If the threshold potential is too low, even slight stimulation is "allowed to enter" and is detected by the neurons. This causes the neurons to fire, resulting in sensory overload. If the threshold is dropped to nothing, all stimuli get through and the neurons fire continuously, resulting in a seizure. If the threshold is raised, only stronger stimuli can make neurons fire. A healthy person’s threshold potential naturally rises at bedtime, promoting sleep. If the threshold potential is too high, you feel drugged or drowsy. If the threshold potential is raised extremely high, coma results.

    Two receptors in the brain, NMDA and GABA, determine the threshold potential. During the waking hours of a healthy person, NMDA and GABA should be equally active. This balances the person in the middle of the seizure/coma continuum. NMDA stimulates, and GABA inhibits. If NMDA increases, one moves toward seizure. If GABA increases, one moves toward coma.

    In CFIDS, NMDA is more activated than GABA, lowering the threshold potential. This causes neurons to fire with very little stimulation, resulting in sensory overload. This condition of excitatory neurotoxicity is dangerous. Dr. Cheney emphasizes that in an attempt to protect itself, the body will eventually kill neurons that fire excessively. He states that brain cell loss can result if this condition isn’t addressed.

    How can the brain be protected against excitatory neurotoxicity? Klonopin. This long acting benzodiazepine has been Dr. Cheney’s most effective drug for CFIDS over the years. He believes that Klonopin and the supplement magnesium may be two of the most important treatments for CFIDS patients because of their neuroprotective qualities. He recommends two or more 0.5 mg tablets of Klonopin at night. Paradoxically, very small doses (usually a quarter to a half a tablet) in the morning and mid-afternoon improve cognitive function and energy. If the daytime dose is low enough, you’ll experience greater clarity and think better. If the daytime dose is too high, you’ll become drowsy. Adjust your dose for maximum benefit, taking as much as possible without drowsiness. Adjust the morning dose first, then take the same amount mid-afternoon if needed, then take three to four times the morning dose at bedtime. Dr. Cheney recommends doubling the dose during severe relapses.

    Dr. Cheney most frequently prescribes the combination of Klonopin and Doxepin, along with the supplement "Magnesium Glycinate Forte." Magnesium Glycinate alone is a good choice for the more budget minded( sells it as "Magnesium Plus".) A common dosage of magnesium is 200 mgs at bedtime. Too much magnesium can cause diarrhea, though glycinate is usually the best tolerated form.

    Cheney prescribes Doxepin in the form of a commercial elixir (10mg/ml). At low doses, this tricyclic antidepressant acts as a very potent antihistamine and immune modulator. Doxepin acts synergistically with Klonopin to assist sleep, and may improve pain. Patients tend to be very sensitive to Doxepin, which can cause morning fog and fatigue if the dose is too high (5 to 10 mg or higher). He recommends starting at two drops a night and gradually increasing the dose until "morning fog" becomes a problem. Most patients can’t tolerate more than half a cc.

    On a handout entitled "Neuroprotection via Threshold Potentials," Cheney lists six substances that can protect the brain. Under the category "NMDA Blockers" Cheney lists:

    1. Parenteral magnesium and taurine (intramuscular injections of magnesium and taurine, usually given with procaine) 2. Histamine blockers (Doxepin Elixir) Under the category "GABA Agonists" (increases GABA) Cheney lists: 3. Klonopin 4. Neurontin 5. Kava Kava 6. Valerian Root

    Klonopin is taken "day and night"; Neurontin "night, or day and night"; kava kava “daytime only”; and valerian “nighttime only.” The first four are by prescription, the last two are herbs. In my limited experience, only certain patients are put on magnesium/taurine injections, and then only for a limited period before switching to oral supplements.

    Many myths abound concerning Klonopin. When asked about these myths, Dr. Cheney shared the following information.


    When the generic Clonazepam came on the market, many patients switched to it because it was less expensive than Klonopin. Cheney then began hearing that most patients had to take more Clonazepam to get the same effect. Generics aren’t exactly identical to the original products, and with most drugs the slight variations don’t matter. However, most CFIDS patients can tell the difference between Klonopin and its generic form, Clonazepam. Most find Klonopin to be more effective.


    Dr. Cheney was adamant that Klonopin is not addictive. In treating thousands of patients, he has never seen a patient become addicted to Klonopin. He reviewed the definition of addiction, stating that it involves: (1) psychosocial disruption, (2) accelerated use, (3) inappropriate use, and (4) drug seeking behavior.

    Dr. Cheney said a case might be made that Klonopin is habituating. It’s true that it can’t be stopped suddenly. You must taper off of it gradually. However, he was cautious about even calling it habituating. The process of tapering off a drug is not the same thing as withdrawal, a term that implies addiction.

    Dr. Cheney said to keep in mind that Klonopin is given for a physiological problem – excitatory neurotoxicity. It’s prescribed to adjust the threshold potential: to keep neurons from firing inappropriately and being destroyed. He stressed that Klonopin should never be given unless you intend to raise the threshold potential. He stated, "Problems arise when you begin to use benzodiazapines for reasons other than threshold manipulation." However, CFIDS patients have a "threshold potential aberration" and need Klonopin (or something similar) to avoid brain injury. Dr. Cheney has never seen a recovered patient have difficulty coming off Klonopin. He stated, "When you no longer need the drug, coming off it is very easy."

    On the other hand, trouble arises when someone who still has an injured brain tries to come off Klonopin. It’s like a thyroid patient stopping their thyroid medication. Dr. Cheney warned, "All hell breaks loose". However, it’s not because the drug is addicting, and it’s not withdrawal. The condition still exists, and the body lets you know it has a legitimate physical need for the drug. Cheney stated, "When a CFIDS patient who is still experiencing the underlying mechanisms of brain injury goes off Klonopin, there is a burst of excess neural firing and cell death. That’s the havoc we hear about that is mistakenly called withdrawal."


    Dr. Cheney said that he honestly doesn’t understand this concern. He believes Klonopin might disrupt the sleep of people who take it for conditions other than the threshold potential aberration found in CFIDS. He also acknowledged that if you are looking just for drugs to facilitate sleep, Klonopin is certainly not the first one to come to mind, nor should it be used to induce sleep in "ordinary" patients. It’s not a sleep drug per se. However, a large part of the sleep disorder of CFIDS is excitatory neurotoxicity and the resulting shift toward seizure. If you treat this condition with Klonopin, then you have treated a large part of the sleep disorder in CFIDS. Most importantly, he said he simply does not see stage 4 sleep disruption in his patients on Klonopin.

    Towards the end of this discussion on Klonopin, Cheney smiled, and remarked, "But suppose I’m wrong about the brain injury and the threshold potential aberration and the shift toward seizure? What if I’m wrong about your need for Klonopin? I’m absolutely sure I’m right, but what’s the worst case scenario? Do you know what long-term studies on Klonopin have shown? Reduced incidence of Alzheimer’s Disease. Alzheimer’s Disease is a complicated and convoluted way of knocking out your neurons, and Klonopin protects your neurons. Now it’s believed that Klonopin didn’t actually stop Alzheimer’s. It just delayed its onset so long that everyone died of something else before they ever got it - which is to say you won’t get Alzheimer’s. You’ll die of something else first."

    The last question Cheney addressed concerned the dose: what happens if the dose is too high? He said the only down side was that if you took a little too much (we are not talking overdose here) it would shift you toward coma on the continuum. It would shut your brain down to some degree, and thus impact your ability to function. This is inconvenient, but it’s not harmful. In fact, it shifts you into the "healing state" on the continuum. You may feel like a zombie, but your brain is protected and your neurons are not getting fried. However, not being able to function isn’t an option for most of us, so we need to find the maximum dose that doesn’t make us drowsy.

    Dr. Cheney emphasized that Klonopin, Doxepin, and magnesium are very, very good at protecting the brain from cell death due to excess firing. However, they can’t stop the underlying mechanisms of CFIDS that are injuring the brain in the first place.

    Though it can’t stop the underlying mechanisms causing the injury, Klonopin can protect your brain and keep your neurons from being destroyed. Then, as Cheney put it, "When you come out on the other side of this, you’ll have more of your brain left."

  12. Marta608

    Marta608 Member

    Nerve would be more like it. I've been on my last one since June.

  13. 1sweetie

    1sweetie New Member

    I was going to reply to you and tell you how Sensory Overload nearly pushed me and my family over the edge. I could not tolerate anything...noise...smells...motion...lights...just about everything and then I saw Mikie's post to you and I was so glad. She was a Godsend to me.

    I thought I could not handle it anymore nor could anyone around me. After reading a post from Mikie about Sensory clicked that was the problem. I was crying constantly. Everything was like fingernails on a chalkboard. Being irritable was not the right word. In 25 years of marriage my DH had never used the "b" word but it finally came out and it was true. I could not help it. It was not the normal "me" at all.

    I had to spend much of my time alone where I could control everything. I was blessed to have a bonus room in my home that I could move to. I began taking small doses of Klonopin during the day...not just at night for sleep. I was still in very bad shape. I had no life and all of this was happening along with all the regular CFS/FM problems. I found that relaxation music became a blessing. It calmed my body.

    My DH bought me one of the new Boise noise reduction headphone sets. I wore them to help block out the noise. They were a blessing also. Yet I was still in bad shape.

    I was behaving and feeling the same way an autistic person would feel if exposed to stimulation with a combination of someone with ADHD. I was a mess. I was also sensitive to most medications.

    Finally a doctor listened and knowing I could not take AD's and having neuropsych test showing it was effecting the frontal lobe of my brain and causing rather severe cogntive dysfunction, they decided to experiment with mood stabilizers. The first one Lamitical gave me the deadly rash it can produce on the 11th day. They then switched me to Abilify, a drug that is usually for Bi-Polar. I take the smallest dose possible ...less than 2 ml. It has been a miracle for me.

    My doctor explained that because of the sensory overload problems, that is why I can not take normal doses of medication. This tiny amount has changed my life.

    It along with the music, Klonopin, the headphones, and preemptive rest has helped so with the sensory overload for me.

    I wanted you to know that you are not alone and do not give me...I nearly did.

    ((((Many Hugs to All of You)))
  14. Mikie

    Mikie Moderator

    Are horrible. It makes us question whether we are losing our minds. It also makes our cognitive problems worse. The slight state of seizure produces such horrible symptoms and it is so wonderful to find a med which stops it all. Klonopin may not be the answer for everyone but it has been a God send for me.

    As I continue to improve, I am finding I almost never have to take even tiny doses now during the day. I have it with me just in case but now I can shop and eat out and the background noise doesn't drive me nuts.

    It was good to know that it was all caused by a chemical imbalance in my brain and that I wasn't going insane.

    Love, Mikie
  15. LittleBluestem

    LittleBluestem New Member

    I used to feel edgy all of the time. Alprazolam (Xanax) pretty well took care of it. If you don’t want to start with a pharmaceutical, things such as Rescue Remedy and Calms Forte may help.

    I wonder if rebounding might also help. The disregulated autonomic nervous system may be the cause of the edginess.

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