Anybody taking or have tried Milk Thistle?

Discussion in 'Fibromyalgia Main Forum' started by peachbunnee, Jan 4, 2006.

  1. peachbunnee

    peachbunnee New Member

    I've read that it's good for the liver, which is another place toxins and such can hang out.

    Wonder if people have had success with it or what?

    Were you on meds, too, when you took it? Any interactions?

    Feedback appreciated as always! :)

    peach
  2. Bailey-smom

    Bailey-smom New Member

    I will be watching this. I was hoping I could take this to counter act the effects of my cymbalta so my #s stay down. I don't want to go off it again!

    Kelly
  3. Countrymom

    Countrymom New Member

    Yes,
    I am taking milk thistle to support my liver. My numbers have been high they think because of the Lyme disease but my last set of labs came back....NORMAL.

    It is supposed to be fantastic for your liver and it looks as if it worked for me!! I am on a ton of hormones, herbal remedies and antibiotics, haven't had any interactions.

    Good luck,
    Dani
    [This Message was Edited on 01/04/2006]
  4. kbak

    kbak Member

    Peach,
    I take milk thistle and would recommend it to anyone, especially those taking meds. It really helps detox your liver. As with many herbs you shouldn't take them everyday. I take it 5 day's a week and 2 off, that way you don't build up to much in your system. I take many different things and haven't had it interfer with anything. You can check potential interacts at a site called www.drugdigest.com.

    K.
  5. sdown

    sdown New Member

    I started taking it 5 years ago. The three years I took 3 tablespoons a day. Now I take 1-2 tbps. a day. I told my doctor and she agrees with it. I had a liver test done 3 years ago and it came back normal. I am due for another one. I definitely recommend milk thistle. The liquid form is better as it goes into your bloodstream faster. My doc said anything you take is better in liquid form.
  6. proteinlady

    proteinlady New Member

    My beta blocker is processed by the liver enzyme CYP3A4. Milk thistle decreases the activity of this enzyme. As a result blood levels of my beta blocker increased and my heart rate became to slow. I had to discontinue the milk thistle. I pasted info from researchers at the University of Pittsburgh below.


    Researchers at the University of Pittsburgh have suspected that milk thistle can slow down or reduce the activity of enzymes in the liver. What does this have to do with HIV? you might ask. Well, enzymes in the liver break down many of the substances that we eat and drink, including medications. If the activity of these enzymes are reduced, then drugs remain in the blood longer than they otherwise might. This could lead to having higher-than-expected levels of drugs in the body, causing side effects or intensifying already-existing side effects. Indeed, in recent experiments using milk thistle and human liver cells, the researchers found that relatively small concentrations of milk thistle did significantly slow down the activity of the liver enzyme CYP3A4 by 50% to 100%.

    Many medications taken by people with HIV/AIDS (PHAs) -- such as protease inhibitors and non-nukes -- are processed by this liver enzyme. If milk thistle is taken by someone using protease inhibitors or non-nukes, it has the potential to raise levels of these drugs, causing unpleasant or even dangerous side effects. Below is a short list of some other medications that are processed through the CYP3A4 enzyme. Levels of these medications may increase if taken by people who are also using milk thistle. This list is not exhaustive:
    * methadone
    * heart drugs -- Tambocor (flecainide), Rythmol (propafenone)
    * antibiotics -- erythromycin, rifampin
    * anti-seizure drugs -- carbamazepine (Tegretol)
    * antidepressants -- St. John's wort, Zyban/Wellbutrin (bupropion), Paxil (paroxetine), Prozac (fluoxetine), Luvox (fluvoxetine) Serzone (nefazodone), Zoloft (sertraline), Effexor (venlafaxine)
    * antihistamines -- Hismanal (astemizole), Seldane (terfenadine)
    * antifungals -- itraconazole (Sporanox), Ketoconazole (Nizoral)
    * gastrointestinal motility agents -- Prepulsid (Cisapride)
    * ergot drugs -- Ergonovine, Ergomar (ergotamine)
    * anti-psychotics -- Clozaril (clozapine), Orap (pimozide)
    * sedatives/sleeping pills -- Ambien (zolpidem), Halcion (triazolam), Versed (midazolam)
    * lipid-lowering drugs (statins) -- Lescol (fluvastatin), Mevacor (lovastatin), Pravachol (pravastatin) and Zocor (simvastatin), Baycol (cerivastatin)
    * transplant drugs -- cyclosporine (Neoral, Sandimmune), ProGraf (tacrolimus)

    Milk thistle also has the potential to lower levels of the following drugs:
    * anti-parasite drugs -- Mepron (atovaquone)
    * sedatives/sleeping pills -- Ativan (lorazepam)
    * hormones - estrogen

    The research by the scientists in Pittsburgh should emphasize to readers that simply because a product is "natural" it does not mean it is safe when taken with other substances. This research also shows the need to conduct further research on herb-drug interactions on liver cells as well as in people. Such studies may find combinations of herbs and drugs that can be safely used together.

    The Pittsburgh researchers noted that "patients and health care professionals must be encouraged to discuss the use of herbs and be educated about the potential interactions between herbs and drugs." This cannot be stressed enough.

    Reference
    * Venkataramanan R, Ramachandran V, Komoroski BJ, et al. Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures. Drug Metabolism and Disposition 2000;28(11):1270-1273.



  7. rockgor

    rockgor Well-Known Member

    FOR a couple months. Never noticed any effect at all.