I have just started using Relaxin in hopes it could help free up my head/neck/shoulder spasms due to constant sinusitus headaches, and maybe even allow the sinuses to drain ...seems like it might be working!... or I'm just in another occasional period of remittance. I'm thinking my muscle spasms are more myofascial /trigger point in nature, since I have points all over the area that refer pain, but this sounded like something that could really be helpful. It's also mentioned in Dr. Starlanyl's book about FM and myosfascial pain. I've also just started myofascial release therapy (only 2 session so far), with great hope. For those who haven't heard about it: "Relaxin is a type of hormone that occurs naturally in humans and other animals. It consists of 56-amino acids in a polypeptide chain, related to insulin. Its presence was first established in the 1930s. In that study, doctors found that it helped relax the pubic ligament during pregnancy.1 In the ensuing decades, doctors refined their understanding of the hormone, but maintained the focus on its role in pregnancy. Although relaxin has been known as the "third pregnancy hormone," it's found in men as well. And while its amazing effects on the body during pregnancy have continued to receive the most attention, researchers have begun to examine its effects on other bodily functions--with significant results. Creates flexible, elastic connective tissues Relaxin's effects during pregnancy are far-reaching and offer a preview of its powerful possibilities. It causes the cervix to "ripen," promotes the widening of the pelvis, thickens the endometrium, and develops blood vessels in the uterus. It softens the tissues of the birth canal and promotes cell proliferation, which helps the cervix and uterus to grow. It also allows ligaments and other connective tissues to relax and elongate.2 This is necessary to accommodate a growing baby in the body. By affecting collagen production and stimulating skin growth, relaxin effectively transforms the female body during pregnancy. Now researchers are beginning to understand the hormone's other responsibilities in the body--in both women and men. Powers beyond pregnancy: Dr. Samuel Yue at the Minnesota Pain Center in St. Paul was among the first to recognize the significance of relaxin's powers beyond pregnancy. Through his work with fibromyalgia patients, he made an important observation. He noted that his female FMS patients reported relief from their symptoms during pregnancy, as well as fewer symptoms before and during menstruation and during menopause. During pregnancy, relaxin concentrations increase from normal levels (below 200 picograms per ml of blood) to over 800 picograms. Before and during menstruation, and during menopause, its levels fall below normal levels. Dr. Yue made the connection between the relaxin levels during these time periods and the relief of FMS symptoms. After further research, Dr. Yue began to treat some of his FMS patients with relaxin derived from pigs, which has a composition very similar to the human hormone. The results were significant. Many of his patients experienced relief from the chronic pain of FMS for the first time. Some felt results immediately, while others took seven to 10 weeks or longer. Until now, doctors had only been able to mask the symptoms of fibromyalgia and had no clear understanding of the causes of the disease. Now Dr. Yue's research offers a clear indication that FMS may be caused by a relaxin deficiency, or the body's inability to utilize the hormone properly. "