Anyone have positive AntiDNA, positive smooth muscle antibody???

Discussion in 'Fibromyalgia Main Forum' started by TerryS, Aug 26, 2006.

  1. TerryS

    TerryS Member

    I have had rheumatic fever, reactive arthritis, and cytomegalovirus in the past.

    Recent lab work has shown positive chronic/recurrent epstein barr, positive Anti-DNA, and positive smooth muscle.

    Anyone else have the positive Anti-DNA and smooth muscle? Wonder where they fit into the picture. The doc who did the tests (an ENT I saw for dizziness) said he thinks I may have CFS.

    TERRY
  2. Shannonsparkles

    Shannonsparkles New Member

    This is new to me. What does it mean?

    By the way, welcome to the board!
    (( )) Shannon
  3. TerryS

    TerryS Member

    Thanks for the welcome!

    From what I find on the internet, looks like the Anti-DNA can be linked to lupus and/or any autoimmunine disorder. The smooth muscle antibody has a strong link to autoimmunine hepatitis (ouch!) but it appears can also be linked to just autoimmune disorders in general.

    I haven't been the same since 2002 when I had the cytomegalovirus (cousin to mono). The epstein barr panel is the marker and appears to show a recurrence or chronic infection. A lot of days, I feel like I've been run over by a truck. My extremities hurt almost continuously - from mild and annoying to severe. I have worsening dizzy spells with "brain zaps", along with a host of other strange symptoms.

    Also, diagnosed this spring with mitral valve prolapse with regurgitation. I notice my chest pounds after mild exertion and I'm out of breath.

    All this, and I'm only 45!!!

    I'm a medical transcriptionist and work from home (thank GOD!). But a couple of hours of sitting up and typing wears me out and I have to rest for a few minutes. I can't sit more than a maximum of 3 to 4 hours before I have to stop and take a nap. I sleep 10 or 11 hours per day.

    It takes me from 8 am until sometimes 9 pm to get my 8 hours of work done. Obviously, the housework, laundry, and cooking NEVER get done. My 67 year old mom comes over from time to time and cleans my house and does my laundry.

    I'm currently on a two-week leave of absence from work to get some rest. I can work 32 hours a week and still be considered full time and keep my STD and LTD benefits. I'm considering trying to do that (back off to 32 hours) if they will accomodate me. I can't afford to be out of work with no pay. I have two kids in college and another in high school!

    TERRY

  4. Cromwell

    Cromwell New Member

    Is this the same or different to ANA?

    I have very high titers of ANA every time they test.

    My rheumy told me that it was probably my Hashimotos but the thyroid doctor said that was an out of order comment as Hashimotos does not show as ANA. I would have thought the Rheumy knew that, so good to check these things.

    Love Anne
  5. TerryS

    TerryS Member

    It's different than the ANA. I think my PCP may be checking that with my last round of blood work.

    I do have bilateral thyroid nodules and my TSH is 4.5, which was within range, but now they have adjusted that scale back to 3.0 being maximum. However, my PCP doesn't want to hear anything I have to say...he's the DOC (or maybe God, Jr.???) I don't mean to pick on him, because in a lot of ways I really like him. I've realized recently that the problem is that he thinks he can handle ANYTHING and never refers you out to a specialist. Fortunately for me, I don't need his permission with my insurance company!!!

    Terry
  6. Bunchy

    Bunchy New Member

    Yes I tested positive for this but they said it could be due to a recent virus (had not had one to my knowledge for months before the tests)

    Talked to several docs about this - they don't seem concerned (and don't care!!) and said it was a "vague" result which doesn't mean anything unless other tests come back positive and then they can put two and two together etc.

    I have come to the conclusion that it is just part of the CFS/FM

    Hugs Bunchy xxx
  7. TerryS

    TerryS Member

    They don't know the why of it, so they blow it off! BUT, it means SOMETHING!!! Just got to put the pieces together. That's exactly what I'm asking my PCP to do...help me put together the pieces. I'm tired of being tired!!!

    Thanks, Bunchy,

    Terry
  8. TerryS

    TerryS Member

    Yeah, I saw the info about the change of TSH level to 3. I mentioned this to the ENT that I saw (he's the one who was so concerned about me) but I he made no comment on it. He said "I know you wish the number was lower, but it's within limits and I wouldn't treat someone with a 4.5 level."

    I haven't mentioned anything else to my PCP about it because he argues with me. He's the one that told me that I don't have MVP becuase he couldn't hear the click. (I'm taking him copies of my records from the MVP Center this Friday). He also looked at the epstein barr panel that the ENT ran (which plainly showed a chronic/recurrent epstein barr infection) and said "that's negative." The interpretation chart was right there on it. The ENT saw it, I saw it, why couldn't he see it. The ENT thought maybe CFS because of the epstein barr panel which is often positive with CFS. Is it positive with FM, also? I figured I'd take EVERYTHING to the rheumatologist and hopefully he can start putting the puzzle pieces together.

    Will the rheumatologist be able to interpret my thyroid results and perhaps order the rest of the panel for me? My PCP didn't order anything but the TSH.

    THANK YOU FOR EVERYTHING!
    Terry
  9. PVLady

    PVLady New Member

    Do you mean positive ANA? Anti-Nuclear Antibodies. It is a indicator for immune problem, possibly Lupus.

    I also have elevated ANA. I have had alot of tests and am waiting for results.

  10. TerryS

    TerryS Member

    It was positive for Anti-ssDNA. I guess there's a dsDNS and an ssDNA...I don't understand the difference!!! I think he may have ordered ANA this time, but I don't really remember now. The only thing I'm positive of is that he ordered vitamin D level.
  11. TerryS

    TerryS Member

    Just found my paper showing what he ordered last week:

    ANA
    C-Reative Protein
    Hepatic Function Panel (has been abnormal in the past)
    Rheumatoid Factor
    SED Rate
    Uric Acid

    plus two that he wrote in. looks like:

    ASO
    ????? D (can't make that one out)

    Previous B-12 down around 400. Repeated and was down to around 200. (Don't have a copy of this).

    Previous liver enzymes were elevated, but this was due to the cytomegalovirus.


    The blood work results from ENT were:

    EBV Early Ab Antigen IgG at 224 (positive at 120)
    EBV Ab VCA IgG at 3580 (positive at 120)
    EBV Nuclear Antigen 1295 (positive at 120)
    and in plain bold print "EBV, Chronic/Active Infection"

    Sjogren's AB, Anti-SSA/SSB - both negative
    Scleroderma profile - all negative
    Lyme disease - negative

    Anti-DNA (SS) IgG, Ab, Qn at 34 (positive at 25)
    Actin (smooth muscle) Antibody at 21 (weak positive from 20 to 30)



    TERRY