Anyone on Pregabalin?

Discussion in 'Fibromyalgia Main Forum' started by NewEnglander, May 17, 2003.

  1. NewEnglander

    NewEnglander New Member

    Heard some good things about this med, wondering if its true and if anyone elses knows about it?
    Lisa
  2. NewEnglander

    NewEnglander New Member

    Let me know if you find out anything life dancer
    thanks
    Lisa
  3. Mikie

    Mikie Moderator

    Amer College Rheum Annual Meeting Presentation Oct 2002

    Pregabalin Improves Pain Associated with Fibromyalgia Syndrome in a Multicenter, Randomized, Placebo-Controlled Monotherapy Trial

    Leslie Crofford, I. Jon Russell, Philip Mease, Ann Corbin, James Young, Jr., Linda LaMoreaux, Susan Martin, Uma Sharma, Lloyd Knapp, Mark Versavel, R. Michael Poole

    Purpose: Fibromyalgia syndrome (FMS) patients experience chronic widespread musculoskeletal pain in association with fatigue and sleep disturbance. There are no approved therapies, and treatments that are used often do not provide adequate relief. This 8-week randomized, double-blind, placebo-controlled, parallel-group monotherapy trial evaluated the efficacy and safety of pregabalin up to 450mg/day (150 mg TID) for reducing pain and associated symptoms in patients with FMS.

    Methods: Patients meeting the ACR criteria for FMS completed a 1-week baseline phase and an 8-week fixed dose treatment phase (6 required visits). Patients (n=529) were randomized to receive placebo, 150, 300 or 450mg/day pregabalin at Visit 2. The primary efficacy parameter was pain, recorded by patients in a daily pain diary, using an 11-point numeric rating scale. The primary analysis was based on the endpoint mean pain score. Secondary efficacy measures included the Short Form McGill Pain Questionnaire (SF-MPQ), sleep quality diary, Medical Outcomes Study (MOS)-Sleep Scale, Multidimensional Assessment of Fatigue (MAF), Patient and Clinical Global Impression of Change (PGIC, CGIC), and SF-36 Health Survey.

    Results: Pregabalin-treated patients (450mg/day) showed significant improvement in the endpoint mean pain score (-0.93; p<0.001) compared to placebo, and were significantly more likely to have 50% reduction in pain from baseline (29% vs. 13%, p = 0.003). The mean SF-MPQ total pain descriptor and visual analog scale (VAS) scores were significantly improved at each visit and at endpoint for the pregabalin 450mg/day treatment group compared to placebo. Mean sleep quality, fatigue, CGIC and PGIC scores at endpoint were significantly improved for patients receiving 300 and 450mg/day pregabalin. The MOS-Sleep Index score was significantly improved at endpoint for all doses. Four of 8 domains of the SF-36 were significantly improved at endpoint for the 450mg/day treatment group. Overall, 48 patients (9%) withdrew due to adverse events and 44 patients (8%) due to lack of efficacy. The most common adverse events were dizziness and somnolence. Most patients (78%) completed the trial and entered a follow-on safety trial.

    Conclusions: Pregabalin is effective and safe for the treatment of pain at 450mg/day in patients with FMS in this study. Pregabalin additionally improved sleep quality, fatigue, global measures of improvement and quality of life.

    ***************************************

    Klonopin, which also works on GABA in the brain, is currently being studied for it's possible pain killing properties. It appears that in quieting the misfiring of neurons in the brain, it disrupts the pain signals as well.

    Klonopin is typically used in our illnesses for anxiety, sleep, and sensory overload. It has been a God send for me. I wonder what benefits Pregabalin might offer over Klonopin. Any of our medical professionals have an opinion?

    Love, Mikie
  4. jka

    jka New Member

    it's suppose to be approved by the fda within the next year for fibro.there are studies about it on internet.my rhumy-who is doing a study on mirapex-says it doesn't work as well as mirapex does.but then again he is studing it.so who knows.
    kathy c