I was just wondering if anyone takes SAMe or other such supplements with their antidepressant. I am aware that these really shouldn't be taken together but still want to know if anyone does anyway. I have not tried it. I have been on effexor xr and will continue to take it because I need it. I have had depression most of my adult life and some of my teen life. I have always had to be on some type of antidepressant and when I wasn't I paid for it. But never tried any supplement when I wasn't on one because back then I didn't know of such supplements. Now that I am on effexor, I won't try to wean off of it unless some doc tells me it is medically necessary. I have never felt real good on any anti-d. Seems like it just keeps me from going off the deep end. If I could take a supplement, I was thinking maybe I would feel better. Don't tell me to ask doc to try another anti-d. I have probably taken most of them over the years. I just want to feel better but not willing to try the others. Any info from anyone is appreciated. Thank you, Lana P.S. I am on quite a few supplements already. Such as magnesium, MSM, Vit C, B complex multivitamin, vit E.