Anyone tried 'new' (?) artesuante or Hepalin for babesiosis or herpes?

Discussion in 'Lyme Disease Archives' started by victoria, Jul 13, 2009.

  1. victoria

    victoria New Member

    I was just reading about artesunate, a new form of artemesinin:
    Artesunate is a water-soluble ‘artemesinin’ drug derived from the ‘sweet wormwood’ plant, Artemsia annua, an herb used to treat infections and other illnesses in China for centuries. Interestingly, according to Wikipedia artemsia was lost as an herbal remedy in China until 1970 when an ancient Chinese medical manual dating back to 340 AD was found. The active ingredient in the plant - artemesinin - was isolated by scientists and it anti-malarial properties were quickly noted (1972). It is now used to treat malaria and schistosoma infections.

    Malaria - Artemesia annua is native to China but has become naturalized around the world including the eastern United States. Artesunate was recently approved for emergency use in patients with severe malaria in the United States. Artemesinin drugs are typically well tolerated but can cause nausea, vomiting, headaches and dizziness. In April 2009 the FDA approved CoArtem which contains a derivative of artemesinin and a broad spectrum antibiotic called lumefantrine.

    Upon binding to infected red blood cells artesunate triggers the release of oxygen and carbon-based free radicals that attack proteins in the parasites. Artesunate also reduces anti-oxidant activity in the red blood cell thus exposing the cell to high free radical levels. Artesunate is currently being studied as an adjunct to chemotherapeutic agents because of its ability to induce cancerous cells to commit suicide (apoptosis) by inducing high rates of oxidative stress. The ability of the antioxidant NAC to thwart Artesunate’s effects in one study substantiated the important role increased free radical production plays in the drugs effect.

    Herpesviruses - Recent culture cell experiments indicated Artesunate was effective at significantly reducing viral protein production in HHV-6A infected cells. A 2005 in vitro study suggested Artesunate significantly reduced cytomegalovirus replication in cells. Because Artesunate effects HHV-6 early in its life cycle it may hold special promise in the kind of smoldering infections that may occur in chronic fatigue syndrome (ME/CFS). Artesunate’s effects on herpesviruses, however, have not been well studied with just five studies published to date. Interest in this drug appears to be increasing, however, three of the five studies were published in 2008.

    Artesunate is in the class of medications known as artemesinins, which are derivatives from the "quinghaosu" or sweet wormwood plant (Artemisia annua). It is used often for the treatment of malaria. Artesunate is available from Hepalin, a California company, their product being called Hepasunate.
  2. Nanie46

    Nanie46 Moderator

    Hi Victoria,

    I have not tried artesunate, but I have also read about it.

    I am taking artemisinin, although my LLMD says he thinks that artemisia might be better than artemisinin because it is in a more raw form.

    Everything I read says to use artemisinin instead of artemisia because it is more potent, but he said it is more processed and sometimes the more raw form might work better.

    Neither of us have been able to find any studies comparing the effectiveness of them.

    My LLMD said he and his wife herxed when taking artemisia, but not artemisinin.

    I would be interested to hear anyone's experience with artesunate.

    Thanks for posting the information.