If others are interested, I'd like to start a discussion about what a cfs doctor once described to me as "dysautonomia." It means an inability to control autonomic functions like blood pressure and heart rate. I'll mention just a few particulars in this message and follow up with more info if there is interest. I've had cfs for almost 20 years and I have many of the classical symptoms. For example, I've been reading with great interest the results of the Montoya study because I am one of those cfs patients with extremely high EBV titers. Those of you who have been dealing with this as long as I have may remember that there was a similar excitement about studies being done by Dr. Hugh Calkins at Johns Hopkins in the early 1990's. He found that many cfs patients had "neurally mediated hypotension" (NMH) as measured by what's called a tilt table test. I went to Johns Hopkins and had the test done and I tested positive. That was quite an experience in itself, including the fact that I was bedridden and unemployed at the time, so I had to pay the several thousand dollars myself to have it done. Unfortunately, the enthusiasm tended to die down afterwards because they were unable to show that the usual treatments for NMH worked for cfs suffers (florinef, beta blockers, etc). I am seeing a new doctor in Seattle and I mentioned that when I stand up, I start to sweat and my heart races. He asked me to show him, so I stood still for 3 minutes. In that time my heart rate shot up to the 130's and my blood pressure shot up to 180/140. He said, "Now that's impressive." He pointed out to me that there is a new name for this. It's called POTS (Postural Orthostatic Tachycardia Syndrome). There's a nice website about it here: http://www.dinet.org/ It's known that an unusual number of POTS sufferers have cfs. Let me also point out that there was a great article published about this just last month in a medical journal called Circulation: http://circ.ahajournals.org/cgi/content/full/117/21/2814 I'm particularly curious about the fact that they recommend treating people with Mestinon. This is also known as pyridostigmine, which you might remember from the first Gulf War (they gave it to soldiers to combat nerve gas and some people think it made them sick). I plan to ask my doctor about Mestinon the next time I see him. I have lots more I could say, but let me see whether this is a topic that others are interested in discussing.