I just wondered how many of you take B-12 supplements and what has been your reaction to them? I am likely deficient in it simply because I take methotrexate for my JRA and that can cause a deficiency. I just took one yesterday, a pill form, 250 mg and it seemed to make me really anxious at first (my body was like, OMG what are you putting in me now? LOL) This lasted about 30 minutes and then, it was weird, I felt really good the rest of the day! Less muscle twitching, a little less brain fog (not complete, I'd say about 50%), less of that horrible twitching around my mouth and face like I am about to have a seizure or something. And my visual floaters almost went away! I don't know if it's pure coincidence or not. If you take it, how much and how often do you take it? I know when they give the shots, you don't get them every day and you don't get them forever. I didn't take one today, as I was a little more anxious and trembly than usual and didn't want to risk increasing that today.