hi folks, just fyi about my bad reaction to grapeseed extract this week... i'm sure it works well for lots of folks, but when i took it, 2 hrs later i was hit by a wall of exhaustion and brainfog and even weepy-ness. i had taken 100 mg. the next day i took half that amount and was hit half as hard, but still very hard. both days i was unable to function 2 hrs after i took it. weird. then i read on another site this below post (written by a non-native english speaker) and i wanted to re-post it here, in case others find they have a similar bad reaction to grapeseed extract, so they may get a hint as to one possible reason why they had the bad reaction. the below post relates to the methylation cycle, a basic biochemical process in the body. "Dr Amy Yasko does not recommends Grapeseed extract for those with ACE++ (a genetic mutation), because this mutation rises your levels of aldosterone and also of cortisol, and the grape seed extract inhibites an enzyme that inhibites at the same time the cortisol, so its net effect is to raise cortisol too, and this, in fact can affect the [so-called] short route of the methylation cycle (via the BHMT enzyme). Well, this is true for Autism, but it is not so clear if it is true for CFS, since, according to Rich, the effect of the ACE mutation can be aminorated by the downregulation of the adrenal-pituitary-hypothalamus axis seen in the most CFS's sufferers."