BARTONELLA co-infection-- 'psychiatric' symptoms, MORE

Discussion in 'Lyme Disease Archives' started by victoria, Apr 6, 2008.

  1. victoria

    victoria New Member

    Original Article

    Do Bartonella Infections Cause Agitation, Panic Disorder, and Treatment-Resistant Depression?

    Posted 09/13/2007

    James L. Schaller, MD, MAR; Glenn A. Burkland, DMD; P.J. Langhoff Author Information



    Abstract

    Introduction
    Bartonella is an emerging infection found in cities, suburbs, and rural locations. Routine national labs offer testing for only 2 species, but at least 9 have been discovered as human infections within the last 15 years. Some authors discuss Bartonella cases having atypical presentations, with serious morbidity considered uncharacteristic of more routine Bartonella infections. Some atypical findings include distortion of vision, abdominal pain, severe liver and spleen tissue abnormalities, thrombocytopenic purpura, bone infection, arthritis, abscesses, heart tissue and heart valve problems.

    While some articles discuss Bartonella as a cause of neurologic illnesses, psychiatric illnesses have received limited attention. Case reports usually do not focus on psychiatric symptoms and typically only as incidental comorbid findings. In this article, we discuss patients exhibiting new-onset agitation, panic attacks, and treatment-resistant depression, all of which may be attributed to Bartonella.

    Methods
    Three patients receiving care in an outpatient clinical setting developed acute onset personality changes and agitation, depression, and panic attacks. They were retrospectively examined for evidence of Bartonella infections. The medical and psychiatric treatment progress of each patient was tracked until both were significantly resolved and the Bartonella was cured.

    Results
    The patients generally seemed to require higher dosing of antidepressants, benzodiazepines, or antipsychotics in order to function normally. Doses were reduced following antibiotic treatment and as the presumed signs of Bartonella infection remitted. All patients improved significantly following treatment and returned to their previously healthy or near-normal baseline mental health status.

    Discussion
    New Bartonella species are emerging as human infections. Most do not have antibody or polymerase chain reaction (PCR) diagnostic testing at this time. Manual differential examinations are of unknown utility, due to many factors such as low numbers of infected red blood cells, the small size of the infecting bacteria, uncertainty of current techniques in viewing such small bacteria, and limited experience. As an emerging infection, it is unknown whether Bartonella occurrence in humans worldwide is rare or common, without further information from epidemiology, microbiology, pathology, and treatment outcomes research.

    Conclusion
    Three patients presented with acute psychiatric disorders associated with Bartonella-like signs and symptoms. Each had clear exposure to ticks or fleas and presented with physical symptoms consistent with Bartonella, eg, an enlarged lymph node near an Ixodes tick bite and bacillary angiomatosis found only in Bartonella infections.

    Laboratory findings and the overall general course of the illnesses seemed consistent with Bartonella infection. The authors are not reporting that these patients offer certain proof of Bartonella infection, but we hope to raise the possibility that patients infected with Bartonella can have a variety of mental health symptoms. Since Bartonella can clearly cause neurologic disorders, we feel the presence of psychiatric disorders is a reasonable expectation.


    [This Message was Edited on 04/06/2008]
  2. victoria

    victoria New Member

    full article at public health alert april 2008 issue
    http://www.publichealthalert.org/Bartonella%20and%20Die.pdf

    excerpts
    The Bartonella Plague Ignored: A Common Reason Lyme Treatment Fails
    by Dr. James Schaller, M.D.
    < publichealthalert.org/articles/james%20schaller/
    The%20Bartonella%20Plague%20Ignored.html >
    (copy & paste with no space between the / at end of 1st line and beginning of 2nd line 'The', ignore the < & > )

    In a previous article, Ignore Bartonella and Die, in the August 2007 issue of the Public Health Alert, I introduced readers to the amazing and emerging stealth bacteria, Bartonella, that has many species that infect humans and a vast numbers of vectors—far more than Lyme spirochetes or Babesia protozoa or Ehrlichia bacteria.

    In my upcoming book, The 16 ways Lyme Disease Treatment Fails, this infection is one of the reasons for Lyme treatment failure. Please understand that Bartonella is not one of the many listed infections which are occasionally in deer ticks and which is of unclear risk.

    ...this is a blind spot... (and bartonella) is both a very routine and dangerous infection which causes fatigue, virtually every psychiatric and neurological problem imaginable, and can silently hurt every organ. It is one reason I will dedicate 1-2 years to write a textbook on Bartonella diagnosis, body damage and treatments.

    First, the routine testing done at routine labs and even some specialty labs misses this infection routinely. There are just so many species that some labs are giving up looking for Bartonella at the species level, and are going to try PCR at the larger genus level.

    It is amusing to read that 40-60% of USA cats carry this infection, when this is based on junk lab testing. The numbers are much higher in my opinion. (he further talks about one indicator that goes down in testing if there is environmental MOLD present!)

    Second, it is important to realize that Bartonella is not rare. It is all over the world (other than perhaps the) polar ice caps.

    I personally believe based on newer and more aggressive testing that it is more common than Lyme disease. Many are falsely diagnosed with Babesia because they are tired and fatigued, and yet this is a highly common symptom of Bartonella reported in vast numbers of studies. It is a major contributing infection to chronic fatigue and Fibromyalgia symptom clusters.

    Third, Bartonella causes about 20-30 problems with each body organ. And this is merely what we know ... at this time....

    If you read some simplistic articles on Bartonella they treat it like a cold, and falsely assume you need enlarged lymph nodes and a purple, blue or red blood vessel rash or flat rash, and a papule to have Bartonella or “Cat Scratch Fever.” Of course Bartonella is most commonly found without these things.... most people who have any rashes miss them because it takes years to learn how to see them because they often mix in with other common skin vascular findings.

    Fourth, you should appreciate that it is unlikely you will ever be cured of Lyme in the presence of Bartonella. Why?

    Bartonella is a massive immune suppressing bacteria. It can float attached to Red Blood Cells in vast numbers and not even cause a cold or fever... It is because it has ways of shutting down the immune system. It violates many rules of bacteria behavior and this is one reason it has been so seriously missed until recent years.

    ...(a research) article concludes by saying that Bartonella LPS is so powerful that it is being looked at as a treatment for autoimmune diseases. (Popa C, Abdollahi-Roodsaz S, Joosten LA, et al. Bartonella quintana lipopolysaccharide is a natural antagonist of Toll-like receptor 4. Infect Immun. 2007 Oct;75(10):4831-7).

    In conclusion, make sure if you are being treated for “Lyme disease,” that the other critical issues of treatment are not ignored such as:
    Bartonella,
    Babesia,
    Lyme biotoxins,
    Bartonella suppressive endotoxins,
    mold biotoxins, and
    Lyme biofilms ...

    In our highly visual book, The 16 ways Lyme Disease Treatment Fails, out in 8 weeks (June?), we will discuss all of these and other reasons for treatment failure and suggest some ways to kill Bartonella.

    Current traditional and progressive treatments are very poor and given at doses that are too low for too short a time... (and) one reason for such large numbers of relapse in supposedly Bartonella “cured” patients. Also, one usually needs to pulse a treatment with some days off each moth for reasons we will explain in future articles.

  3. victoria

    victoria New Member

    has to be found... that's true with lyme too of course.

    I'd have to dig thru my son's files to find out what he was given specifically for bartonella besides levaquin;

    but levaquin seemed to have been at least for a while extremely effective. He took it as per his doc's usual protocol, three 5-day weeks of taking abx & herxing, 4th week off to let his system rest...

    When he resumed it again, he immediately had a bad response and it was impossible to determine whether it was a major herx or allergic reaction; so he didn't take any more... and was told to let his system really rest after that so didn't do any abx at all for an addition 3 weeks.

    Interestingly, that month of all abx after the levaquin was the clearest he felt cognitively in particular... and the neurocognitive symptoms have been the hardest thing imho for him to clear.

    I think it still needs to be addressed for him... but it will be a few months before he sees his lyme doc again.