So, I"m one of the guinea pigs starting the Methylation unblocking protocol that has been discussed recently. When I added in SAM-e, a sulphur donor, I am getting SCREAMING bladder pain. I just remembered that it does this when I have MSM, tons of garlic (and i do eat a LOT of garlic all the time), anything with EDTA in it. I have had EDTA Chelation and again had HORRIBLE kidney pain from it. If I eat/drink anything with EDTA (like Minute Maid Lemonade) or use hair dye with EDTA, my bladder screams. I'm guessing it is the SAM-e, donating sulfer, that's doing it. Has anyone else had this occur? Especially related to the Methylation unblocking protocol?