British Scientists may have found diagnostic test for CFS!!

Discussion in 'Fibromyalgia Main Forum' started by Jo29, Sep 14, 2005.

  1. Jo29

    Jo29 New Member

    I read an article in the AARP Bulletin that I get(yes I am over 50), about CFS.....

    No Doubt

    People with chronic fatigue syndrome put up with a lot skepticism about their complaints. But a study by British scientists could send the doubters packing.

    A team based at St. George's Hospital in London reported in August's Journal of Clinical Pathology that cartain genes in white blood cells are much more active in those with chronic fatigue than in healthy people. The study does not identify the causes of CFS but it could lead to the first diagnostic test.

    That would be "huge, huge news for CFS sufferers, many of whom have been told it's all in your head," says Marcia Harmon of the CFIDS (Chronic Fatigue and Immune Dysfunction Syndrome) Association of America.

    You can find this article at Sept.2005 issue. P.25

    I thought you all might be as happy to read this as I was.

  2. happygranny

    happygranny Member

    Thanks for posting that Jodi, we need validation for our misery.

    After that we need a cure!!!!

    It is good news.

  3. happygranny

    happygranny Member

    I found this at a BBC News Website:

    Chronic fatigue gene signs found.
    Scientists believe they have pinpointed biological markers of chronic fatigue syndrome which could help develop a test and treatment for the condition.
    CFS, or ME, makes people feel extremely tired, and can cause weakness, headaches, and disrupted sleep.
    Scientists, now based at St George's Hospital, London, found differences in the way genes are expressed in white blood cells of people with CFS/ME.
    But others say the New Scientist findings may not explain all cases.
    It is also due to be published in the Journal of Clinical Pathology.
    The scientists say their findings fit with the understanding that a virus, such as Epstein-Barr, may trigger CFS/ME, because that illness might alter how genes are expressed.
    CFS/ME often first appears as a flu-like illness, but does not then go away.
    The researchers compared levels of gene expression in the white blood cells of 25 healthy people and 25 who had CFS using DNA chip technology.
    They found differences in the behaviour of 35 of the 9,522 genes they analysed.
    Further genetic testing showed 15 of the genes were up to four times more active in people with CFS, while one gene was less active.
    Several genes the team pinpointed play important roles in mitochondria, the "powerhouse" of cells.
    One of the products of these genes is EIF4G1, which is involved in the protein production in mitochondria.
    EIF4G1 is hijacked by some viruses, so cells may compensate by increasing gene expression.
    The genetic differences lead to changes in how blood proteins behave which could allow the development of a blood test for CFS, the team say.
    Other genes are involved in regulating the immune system or playing important roles in nerve cells.
    The team will now carry out further research on 1,000 CFS patients and healthy people.
    Not 'made-up'
    Dr Jonathan Kerr who led the research team, which is currently in the process of moving to St George's, said: "The involvement of such genes does seem to fit with the fact that these patients lack energy and suffer from fatigue."
    He added the work could also potentially lead to a treatment for the condition.
    "We have shown that a significant part of the pathogenesis resides in the white blood cells and in their activity
    "It will open the door to development of pharmacological interventions."
    Dr Russell Lane, a neurologist at Charing Cross Hospital, in London, said: "This exciting new work shows that some aspects of this complex illness may be understandable in molecular terms, and that CFS is not a 'made-up' illness."
    Chris Clark, chief executive of Action on ME, told the BBC News website: "The prospect of having a diagnostic test is very encouraging because many people with ME can currently take well over a year to find out what is wrong with them."
    Dr Neil Abbot of Merge, a charity which funds research into CFS/ME, said: "CFS/ME can have very different effects on patients.
    "We're not looking at just one condition with a definitive patient group.
    "So it might be hard to get a gene signature which works for everyone with CFS/ME."
    But he added: "This research probably won't be the answer for everyone, but it is still very interesting."

  4. orachel

    orachel New Member

    This is fantastic! I'll make sure to read the articl asap! Great post!!!

    Actually, theres a ton of VERY EXCITING AND VERY ENCOURAGING studies in diagnostics and teatment options for FM going on right now, too. I needed a little boost this mornin, so I was actually just rereading a lot of them. I print out everything (articles, medications, inspirational stuff) I find useful with FM and keep it in a cheapo 3 ring binder.

    I found some other really great info on AFSA website (search for afsa...don't know if we can post websites here or not). All kinds of great studies involving brain/CNS imaging (specifically hippocampus function, and mast cells in the thalmus), exercise windup and pain measurement. Plus, they had a really great chart listing all standard medications for FM, plus some new ones that are just gaining popularity, plus dosages, usages, side effects...really cool info. Used this to get my doc to give me Ultram when he didn't want to. Also, lists all the treatment trials going on, so we can check on what's likely to be available eventually.

    If you hunt around, and are willing to sift thru some very technical medical schtuff (there was a lot I didn't understand, but learned TONS about FM that I had never seen posted anywhere else) its a goldmine of knowledge.

    There was even a great article about adding DEXTROMETHORPHAN (COMMON OTC COUGH SYRUP) TO ULTRAM
    in pain mgmt plan for a dramatically increased effect in pain reduction. I'm talking to my doc abt this, because if taking otc cough syrup will possibly make ultram work better, and has almost no side effects, I'm all for it.

    Thanks so much for post, Jodi!
  5. Smiffy

    Smiffy Member

    This is good news. I hope the UK government will now stop wasting its money funding harmful Graded Evercise Programmes, & look for a cure instead.
  6. tansy

    tansy New Member

    will change their current stance until it’s carved in stone; the psychologisers have offered them an easy get out clause. Vance Spence (MERGE) was right to caution about sub sets, if this research is conducted with that in mind, they may well find a way of distinguishing them thereby leading to better treatments protocols for all of us.

    I was Dx 22 years ago, and that Dx confirmed for many years using one of several tests. The first blood test used was a lymphocyte study that showed changed ratios in my T cells – helpers were high, suppressors low and atypical lymphocytes: this was the case even when my lymphocyte numbers went so low they thought I had AIDS.

    Most other PWME in my area were only Dx if this test showed similar altered ratios

    Tansy[This Message was Edited on 09/14/2005]