c3a and c4a test

Discussion in 'Lyme Disease Archives' started by jess, Sep 23, 2008.

  1. jess

    jess New Member

    HI, on the CFS/Fibro board someone metioned this test. If it is elevated this is related to Lyme. It is for Anaphilatoxins. Has anyone had any experience with these tests or know something about them? Thanks, Jess
  2. victoria

    victoria New Member


    what post was it talked about on the main board? I've had a hard time googling anything about it short of this...

    all the best,

  3. victoria

    victoria New Member


    Complement Split Products C3a and C4a Are Early Markers of Acute Lyme Disease in Tick-Bite Patients in the United States (Paper Accepted 2007 for publication in The International Archives of Allergy and Immunology)

    Ritchie C. Shoemaker, M.D.; Patricia C. Giclas, Ph.D.; Chris Crowder, B.S.; Dennis House, M.Sc.; and M. Michael Glovsky, M.D.4*

    From the Center for Research on Biotoxin Associated Illnesses, Pocomoke, MD (R.C.S., D.H.); Pediatrics Department, Allergy and Immunology Division, National Jewish Medical and Research Center, Denver, and NJC Clinical Reference Laboratories, Denver (P.C.G.); Department of Microbiology and Molecular Genetics, UC Irvine, Irvine (C.C.); and Department of Immunology, Quest Diagnostics Nichols Institute, San Juan Capistrano (M.M.G.)


    Background: Current laboratory markers do not readily detect acute Lyme disease. We assessed the utility of complement and its split products as markers of Lyme disease in patients shortly after a tick bite.

    Methods: Thirty-one consecutive acute Lyme disease patients, 14 with and 17 without an erythema migrans (EM) skin rash, seen by a physician within 96 hours of a tick bite were matched with 24 consecutive tick-bite patients without Lyme disease symptoms and 46 healthy control subjects. Complement and split products measured included Factor B, Bb, C4, C3c, C3ades Arg, C4ades Arg, C1q- and C3d-containing immune complexes, and C2.

    Results: C2, C4, C3, and Factor B levels were within normal ranges in all groups. C3a and C4a levels were significantly higher in acute Lyme disease patients than in tick-bite and healthy control groups (both p<0.001). All acute Lyme disease patients, regardless of EM, had elevated levels of C3a or C4a. Few tick-bite controls had elevated levels of C3a (2/20) or C4a (5/24); only one of the healthy control subjects had elevated C3a (0/46) or C4a (1/32).

    Conclusions: These findings suggest that C3a and C4a may be useful markers of Lyme disease in patients seen shortly after tick-bite, even in those without EM.


    I think the important info is in the conclusion - it's likely more definitive for EARLY lyme vs late/chronic/post-lyme.

    I don't know anything more about myself obviously, but, there is more info there about tests and lots more, you might find it interesting.

    all the best,

    [This Message was Edited on 09/23/2008]