Can we have Lupus but no ANA in blood?

Discussion in 'Fibromyalgia Main Forum' started by nice2meetu, Aug 17, 2005.

  1. nice2meetu

    nice2meetu New Member

    When I was diagnosed with fibro my OD told me he thought I had "a little Lupus". Making light of it so i wouldn't get upset. I had alot of symptoms and the redness over the cheeks and bridge of the nose. I was tested twice once again by my Rheumy, no ANA present. But here I am with the symptoms still 3 years later! My skin is getting more and more sensitive to light, and I suffer with dishydrotic exzema that is painful. I also have horrible headaches. So my querry is can Lupus be present without ANA present? I am just curious.
  2. DPgirl

    DPgirl New Member

    There is alot of information out there about this. The ANA test is only one of the things they should look at when diagnosing lupus.
  3. yuckie

    yuckie New Member

    nice2meetu

    My understanding is that some doctors believe that you can have a negative ANA and be diagnosed with Lupus. I believe aproximately 5% of Lupus sufferers are negative ANA. Search the internet for "ANA Negative Lupus". Take care-Janice
  4. JLH

    JLH New Member

    Yes, you can have Lupus with a negative ANA.

    I have systemic lupus, and my ANA comes back negative quite a bit. There are 2 or 3 different types of lupus--the systemic, discoid, and I forgot the 3rd!!! I'm not sure if organ damage is possible in just the systemic lupus or all types.

    Here's some info that you might be interested in reading -- it's some of the symptoms for lupus.

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    TABLE 1. SYMPTOMS OF LUPUS

    Percentage Symptom

    95% Achy joints (arthralgia)
    90% Fever over 100 degrees F (38 degrees C)
    81% Prolonged or extreme fatigue
    90% Arthritis (swollen joints)
    74% Skin Rashes
    71% Anemia
    50% Kidney Involvement
    45% Pain in the chest on deep breathing (pleurisy)
    42% Butterfly-shaped rash across the cheeks and nose
    30% Sun or light sensitivity (photosensitivity)
    27% Hair loss
    17% Raynaud's phenomenon (fingers turning white and/or blue in the cold)
    15% Seizures
    12% Mouth or nose ulcers


    Diagnosis

    Because many lupus symptoms mimic other illnesses, are sometimes vague and may come and go, lupus can be difficult to diagnose.

    Diagnosis is usually made by a careful review of a person's entire medical history coupled with an analysis of the results obtained in routine laboratory tests and some specialized tests related to immune status. Currently, there is no single laboratory test that can determine whether a person has lupus or not.

    To assist the physician in the diagnosis of lupus, the American Rheumatism Association issued a list of 11 symptoms or signs that help distinguish lupus from other diseases (see Table 2). A person should have four or more of these symptoms to suspect lupus. The symptoms do not all have to occur at the same time.


    TABLE 2

    THE ELEVEN CRITERIA USED FOR THE DIAGNOSIS OF LUPUS

    Criterion Definition:

    • Malar Rash
    Rash over the cheeks
    Discoid Rash
    Red raised patches

    • Photosensitivity
    Reaction to sunlight, resulting in the development of or increase in skin rash

    • Oral Ulcers
    Ulcers in the nose or mouth, usually painless

    • Arthritis
    Nonerosive arthritis involving two or more peripheral joints (arthritis in which the bones around the joints do not become destroyed)

    • Serositis

    • Pleuritis or pericarditis

    • Renal Disorder
    Excessive protein in the urine (greater than 0.5 gm/day or 3+ on test sticks) and/or cellular casts (abnormal elements the urine, derived from red and/or white cells and/or kidney tubule cells)

    • Neurologic

    • Seizures
    (convulsions) and/or psychosis in the absence of drugs or metabolic disturbances which are known to cause such effects

    • Hematologic
    Hemolytic anemia or leukopenia (white bloodcount below 4,000 cells per cubic millimeter) or lymphopenia (less than 1,500 lymphocytes per cubic millimeter) or thrombocytopenia (less than 100,000 platelets per cubic millimeter). The leukopenia and lymphopenia must be detected on two or more occasions. The thrombocytopenia must be detected in the absence of drugs known to induce it.

    • Immunologic
    Positive LE prep test, positive anti-DNA test positive anti-Sm test or false positive syphilis test (VDRL).
    Positive test for antinuclear antibodies in the absence of drugs known to induce it.


    Adapted from: Tan, E.M., et. al. The 1982 Revised Criteria for the Classification of SLE. Arth Rheum 25:

    ~~~~~~~~~~~~~~~~~~~~~~~~~~

    Hope this info helps you a little,

    Take Care
    Janet