Cause of Long Term Chronic Pain!! Please Read!!

Discussion in 'Fibromyalgia Main Forum' started by pamsue, Feb 15, 2006.

  1. pamsue

    pamsue New Member

    This article was sent to my email and I found it very interesting, please let me know what you think. Your opinions are very valuable to me since I know that you all study this as well. Thanks

    Clues to cause of long-term pain
    Woman in pain
    Millions suffer from chronic pain
    Undamaged nerve fibres - not those that are injured - may cause long-term chronic pain, research suggests.

    Ongoing pain affects one-in-five adults across Europe, and costs an estimated £23 billion a year in lost work days.

    Inflammation caused by damaged nerve fibres triggered nearby undamaged ones to send signals to the brain, the University of Bristol researchers said.

    In the journal Neuroscience, they say their finding may aid the development of more effective painkillers.

    The cause of this ongoing pain and why it arises spontaneously was not understood before
    Professor Sally Lawson

    Ongoing pain is a burning or sharp stabbing/shooting pain that can occur spontaneously after nerve injury - unlike "evoked" pain caused, for example, by hitting your thumb with a hammer.

    It is particularly difficult to live with because it is often impossible to treat with currently available painkillers.

    Previous research into ongoing pain has tended to focus on the damaged nerve fibres after injury or disease and overlooked the intact fibres.

    Key nerve cells

    Lead researcher Professor Sally Lawson said: "The cause of this ongoing pain and why it arises spontaneously was not understood before.

    "Now that we know the type of nerve fibres involved, and especially that it is the undamaged fibres that cause this pain, we can examine them to find out what causes them to continually send impulses to the brain.

    "This should help in the search for new analgesics that are effective for controlling ongoing pain."

    The Bristol team found that the key was nerve cells called nociceptors, each of which has a very long, fine nerve fibre emerging from it.

    These fibres run within nerves and connect the skin or other tissues to the spinal cord.

    Any research like this that helps us to understand why people suffer from pain should ultimately help us to develop new treatments
    Dr Beverly Collett
    British Pain Society

    When activated through damage or disease, these nerve fibres fire electrical impulses that travel along the fibre from the site of injury to the spinal cord, from where information is sent to the brain.

    The faster the fibres fire, the stronger the pain becomes.

    The Bristol team found that firing seems to be triggered in undamaged fibres by inflammation produced by neighbouring dying or degenerating fibres which have been damaged by injury within the same nerve.

    The researchers said further work was needed to establish how this mechanism might contribute to the ongoing pain associated with a wide variety of diseases.

    Dr Beverly Collett, president of the British Pain Society, said: "This is important because it throws more light on to what happens when people suffer neuropathic pain from trauma, surgery, or conditions like diabetes and shingles.

    "Any research like this that helps us to understand why people suffer from pain should ultimately help us to develop new treatments."

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    University of Bristol
    Journal of Neuroscience
    British Pain Society
    The BBC is not responsible for the content of external internet sites

  2. pamsue

    pamsue New Member


    I am so glad to hear what you are saying. I hope you are right in that they are onto something. So many people are in so much pain and there just seems to be no end in sight

    Thank you so much for your response.

  3. Pianowoman

    Pianowoman New Member

    I think this is part of the story and, of course, any new research into chronic pain will ultimately help us. It seems to me that this talks more about neuropathic pain. Some of us have that type of pain but not all of us so there is more to the story.

    I will be interested in other opinions.

  4. pamsue

    pamsue New Member

    Thank you for your response Pianowoman. The reason I believe that there may be nerve problems in FM people is because we are always in so much pain that it tightness or muscles and makes them so sore and tight all the time it just makes sense that the tighter muscles could cause pressure on the nerves.

    You are probably right though, there probably is more to FM then just this, I just thought it was a good point to share and like you I am looking forward to different responses

    Thanks again
  5. Cromwell

    Cromwell New Member

    Gee, this matches the research my cousin is doing in Boston too, she is the one that puts in pain modulators that look like pacemakers in to pain sufferers bodies.

    As my doc just called to say that my neurologist refuses to see me for another consult as he already saw me once, yes, when he said, he had no idea what my problem was, I guess he could use this education. As it was six months ago and I am still unable to walk a straight line, one may think he would be keen to get another $250 from me for another 15 minute office visit. I am scheduled for an EMG of the leg, and my leg is getting a bit better now, so I don't want the pain of that. He won't switch the appt. to consult only.

    Do you think I should have the EMG done?

    I am CONVINCED that it is nerve pathway responses too and this article and the Boston research and others are on track here.

    Love Anne C
  6. ilovecats94

    ilovecats94 New Member

    It all makes a lot of sense to me too, because my FMS was caused by neck trauma over a period of 6 weeks during weight training with my back on a exercise step and my neck hanging off of it.

    This would make perfect sense that I have damaged nerve fibers.

    I opened 4 windows today and I'm hurting just from that. :(

    Feel well... :)

  7. pamsue

    pamsue New Member

    Cromwell and Ilovecats,

    Thank you so much for your response. I am glad it makes sense to you both as well. I am sorry about your neuro appt cromwell, that is so true though, they worry when they can't figure something out , they don't want to look like they may just not know what it is, so they tell you it is nothing or in your head.

    They seem to just want to do the least they have to with all their patients and like you said it is $250 a pop. Not a bad pay check for 15 min of nothing.

    I am glad there are still some good ones out there, just hard to find

    Hugs to you both

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