ccvi and chronic fatigue?

Discussion in 'Fibromyalgia Main Forum' started by KerryK, Jun 6, 2010.

  1. KerryK

    KerryK Member

    Has anyone heard of any studies into the possibility that ccvi (chronic cerebral spinal veinous insufficiency) is responsible for the fatigue in Chronic Fatigue or FM? If nothing else, it appears to be responsible for much of the fatigue in MS. Anybody?

    Is chronic fatigue the symptom of venous insufficiency associated with multiple sclerosis? A longitudinal pilot study.
    Malagoni AM, Galeotti R, Menegatti E, Manfredini F, Basaglia N, Salvi F, Zamboni P.

    Vascular Diseases Center, University of Ferrara, Ferrara, Italy. mlgnmr@unife.it

    Abstract
    AIM: Chronic fatigue (CF) severely affects patients with multiple sclerosis (MS), but its pathogenesis remains elusive and the effectiveness of available treatments is modest. We aimed to evaluate the effect on CF of the balloon dilatation of stenosing lesions affecting the main extracranial veins configuring the chronic cerebrospinal venous insufficiency (CCSVI), a condition strongly associated with MS. METHODS: Thirty-one MS consecutive patients (16 males, age 46.2+/-9.4 years) with associated CCSVI and CF underwent the endovascular procedure. Fatigue was assessed using the Fatigue Severity Scale (FSS) and Modified Fatigue Impact Scale (MFIS) at baseline (T0) and one (T1), six (T6) and twelve (T12) months after the procedure. In ambulatory patients (N.=28), mobility was evaluated using the 6-min walking test at T0 and T1. RESULTS: and MFIS scores significantly improved from preoperative values, and the positive trend was maintained at one year (FSS: T0=5.1+/-1.0 to T12=3.5+/-1.8, P<0.001; MFIS-total score: T0=34.9+/-14.8 to T12=22.5+/-13.7, P<0.001; MFIS-Physical subscale: T0=21.2+/-8.0 to T12=13.5+/-9.7 P<0.001; MFIS-Cognitive subscale: T0=9.2+/-9.5 to T12=6.0+/-6.3, P=0.03; MFIS-Psychosocial subscale: T0=4.5+/-2.1 to T12=2.5+/-2.1, P<0.001). Six-min walking distance (6MWD) at T1 improved significantly (332+/-190m to 378+/-200m, P=0.0002). In addition, an inverted correlation between 6MWD and MFIS-physical subscale variations was found in the subgroup of patients (N.=8) with no lower limb motor impairment (r=-0.74, P=0.035). CONCLUSION: The reestablishment of cerebral venous return dramatically reduced CF perception in a group of MS patients with associated CCSVI, suggesting that CF is likely the symptom of CCSVI.

    PMID: 20351673 [PubMed - in process
  2. simonedb

    simonedb Member

    I posted about this here awhile ago, not a lot of interest, if you go to ms sites can learn a lot more. I am very intrigued about it though and would like to rule it out. I just got one of those healthline screens you can get and will find out results in couple weeks, I don't know if the screening they do looking at neck for heart issues etc could count as peripheral screen for stuff zamboni talking about........