During the first few years of my CFS I had pronounced alcohol intolerance. My CFS manifests itself as a viral encephalopathy and I don't want to add to it a neurotoxin like ethanol so now I don't drink alcohol at all. What I find interesting is that many friends of mine smoke cannabis and it has anxiolytic and euphoric effects on them. When I smoke cannabis I either feel nothing or start to feel extremely anxious, disoriented and incapacitated. Even one of my friends, who happens to be a neuroscientist of considerable impact and an experienced cannabis abuser in one person, tells me he has never seen such reactions to cannabis smoking. Do you have similar experience?