CFS associated with diminished intracellular perforin

Discussion in 'Fibromyalgia Main Forum' started by tansy, Nov 23, 2005.

  1. tansy

    tansy New Member

    Chronic fatigue syndrome is associated with diminished intracellular perforin.

    Journal: Clin Exp Immunol. 2005 Dec;142(3):505-11.

    Authors: Maher KJ, Klimas NG, Fletcher MA.

    Affiliation: Department of Medicine, University of Miami Miller School of
    Medicine, Miami, FL, USA.

    NLM Citation: PMID: 16297163

    Chronic fatigue syndrome (CFS) is an illness characterized by unexplained
    and prolonged fatigue that is often accompanied by abnormalities of immune,
    endocrine and cognitive functions. Diminished natural killer cell
    cytotoxicity (NKCC) is a frequently reported finding. However, the
    molecular basis of this defect of in vitro cytotoxicy has not been described.

    Perforin is a protein found within intracellular granules of NK and
    cytotoxic T cells and is a key factor in the lytic processes mediated by
    these cells. Quantitative fluorescence flow cytometry was used to the
    intracellular perforin content in CFS subjects and healthy controls. A
    significant reduction in the NK cell associated perforin levels in samples
    from CFS patients, compared to healthy controls, was observed. There was
    also an indication of a reduced perforin level within the cytotoxic T cells
    of CFS subjects, providing the first evidence, to our knowledge, to suggest
    a T cell associated cytotoxic deficit in CFS.

    Because perforin is important in immune surveillance and homeostasis of the
    immune system, its deficiency may prove to be an important factor in the
    pathogenesis of CFS and its analysis may prove useful as a biomarker in the
    study of CFS.

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