CFS: DHEAs and IGF1

Discussion in 'Fibromyalgia Main Forum' started by tansy, Nov 5, 2005.

  1. tansy

    tansy New Member

    Decreased dehydroepiandrosterone sulfate but normal insulin-like growth
    factor in Chronic Fatigue Syndrome (CFS): Relevance for the inflammatory
    response in CFS.

    Journal: Neuro Endocrinol Lett. 2005 Oct 30;26(5)

    Authors: Maes M [1,2], Mihaylova I [1], De Ruyter M [3]

    Affiliations:
    [1] M-Care4U outpatient Clinics, and the Clinical Research Center for
    Mental Health, Antwerp, BELGIUM;
    [2] Department of Psychiatry, Vanderbilt University, Nashville, TN, USA;
    [3] Salvator Ziekenhuis, Salvatorstraat, Hasselt, BELGIUM

    NLM Citation: PMID: 16264414


    There are a few reports that chronic fatigue syndrome (CFS) may be
    accompanied by changes in hormones, such as dehydroepiandrosterone (DHEA)
    and insulin-like growth factor (IGF1). This study examines the serum
    concentrations of DHEA-sulfate (DHEAS), IGF1 and IGF1 binding protein-3
    (IGFBP3) in 20 patients with CFS and in 12 normal controls.

    The IGFBP3/IGF1 ratio was computed as an index for IGF1 availability.

    We found significantly lower serum DHEAS concentrations in CFS, but no
    significant differences either in IGF1 or the IGFBP3/IGF1 ratio between CFS
    patients and normal controls. The decrease in serum DHEAS was highly
    sensitive and specific for CFS. There were significant and positive
    correlations between serum DHEAS and serum zinc and the mitogen-induced
    expression of the CD69 molecule on CD3+CD8+ T cells (an indicator of early
    T cell activation). There was a significant and negative correlation
    between serum DHEAS and the increase in the serum alpha-2 protein fraction
    (an inflammatory marker). Serum IGF1, but not DHEAS, was significantly and
    inversely correlated to age.

    The results show that CFS is accompanied by lowered levels of DHEAS and
    that the latter may play a role in the immune (defect in the early
    activation of T cells) and the inflammatory pathophysiology of CFS.
  2. bct

    bct Well-Known Member

    would seem to be appropriate for CFS patients, if I am reading this properly. What is your take on this, Tansy?

    I have CFS. My DHEA levels are very low, so I have started 25mgs. daily. I was tested by Great Smokies' saliva test.

    Thanks again for your much appreciated posts, Tansy. You have provided an incredible amount of information to the members of this board. Frankly, I don't know how you do it!

    Best Wishes
    Barry
  3. dononagin

    dononagin New Member

    Thanks Tandy.. good info here..
  4. elsa

    elsa New Member

    My test results most definately back up the DHEA-S findings, but differ greatly with the IGF-1. I wonder if they are looking into a subset where both are effected?

    My DHEA-S was laughable and IGF-1 only registering about 30% of what I should be registering. I felt that the months prior to testing while I was taking mucuna pruriens is responsible for the IGF-1 not being worse then 30%.

    I am a firm believer in the HPA axis dysregulation. The more studies I see on this topic the better for us. Testosterone is another hormone that can't help but be effected as DHEA-S leads to it's production.

    I could go on and on about this! LOL .... Better stop now.

    Thanks for posting ... I appreciate your efforts in keeping us informed of the latest study results.

    Elsa
  5. tansy

    tansy New Member

    Barry

    I have avoided DHEA or DHEAs because my sex hormones were so out of kilter I was concerned that as a female it might not be suitable. I took the 7-keto version along with pregnenalone for some months though. Prior to that I took low dose cortef for 3 months and after that an alternative approach to support my adrenals etc. These achieved less than I’d hoped for and some of the recommendations caused me more problems than they solved; Siberian ginseng being just one example.

    Many of us test low for DHEAs and cortisol, my 24 hour saliva test confirmed my skewed circadian cycle, but by noon my DHEAs levels were back in the normal range. Cheney’s 3 stages of CFIDS explains why this is inevitable for so many of us.

    I ended up opting for working on what was affecting my HPA axis, rather than trying to rebalance everything. Now my HPA axis and immune system feel more stable than they have for over 22 years, symptoms related to my thyroid hormones are markedly improved as are those associated with hypoglycaemia/insulin resistance. Like most others it has taken an integrative approach: mostly natural remedies and supps with just one Rx med for sleep.

    Elsa

    Knowledge is empowering. The more we understand our symptoms and why they might be occurring, the better our odds of making informed decisions. So many specialists and researchers have their own preferences; we need to decide what our own preferences are. No one knows our bodies as well as we do, and that’s an important factor many health professionals, mainstream and alternative, often fail to take into account.

    love, Tansy[This Message was Edited on 11/08/2005]
  6. foxglove9922

    foxglove9922 New Member

    Tansy,

    You mentioned you worked on your HPA,,,,,what are you doing to correct it?

    Thanks,,,,,,,,foxglove
  7. tansy

    tansy New Member

    After disappointing results from my Tx, even though test results indicated their usage I changed my protocol. First I slowed down the die off rate whilst I concentrated on the coagulopathy, inflammation, immune deregulation, toxins etc. All these along with infections, can adversely affect the HPA axis. Vit D3 played an important role since it regulates both the endocrine and immune systems. I changed from bromelain and cycling serrapeptase to natto and turmeric; the latter provide multiple benefits, which I also needed.

    My muscle problems alone indicate growth hormone problems, as my haematologist pointed out poor sleep could be the cause of this, since getting more and better quality sleep in the last few months I have been able to rebuild some lost muscle for the first time in over 22 years despite them remaining relatively exercise intolerant. There a homeopathic growth hormone product called Biomed Growth Hormone that has worked well for some with these DDs. I take spirulina and chlorella which seem to have helped in this area and generally too; now I no longer take a multi vit/min, instead I just top up the nutrients I need more of.

    Correcting the ion channelopathy with balanced electrolytes (Recuperation) seemed to help break the negative feedback loop that was stressing my HPA axis, these made a real difference to my thyroid related problems. Before Recup anything with iodine would trigger hyperthyroid symptoms, this included natural sources; now I can tolerate chlorella without this occurring. Coagulation affects the endocrine glands, and vit D3 helps regulate their functions, so as is often the case it took a combo.

    My adrenals (& DHEAs levels) may still need addressing later on, but for the time being I feel I can wait and see if they recover on their own. For some months now I rarely have any indications of the sympathetic dominance so often written about in these DDs.

    love, Tansy[This Message was Edited on 11/19/2005]
  8. foxglove9922

    foxglove9922 New Member

    Many thanks for all the information Tansy,,,,I'm still trying to digest it all. Foxglove