CFS: Exercise Performance Related to Immune Dysfunction

Discussion in 'Fibromyalgia Main Forum' started by tansy, Nov 5, 2005.

  1. tansy

    tansy New Member

    Chronic Fatigue Syndrome: Exercise Performance Related to Immune Dysfunction.

    Journal: Med Sci Sports Exerc. 2005 Oct;37(10):1647-1654.

    Authors: Nijs J [1,2], Meeus M [1,2], McGregor NR [3], Meeusen R [1], DE
    Schutter G [1], VAN Hoof E [1], DE Meirleir K [1]

    Affiliations:
    [1] Department of Human Physiology, Faculty of Physical Education and
    Physiotherapy, Vrije Universiteit Brussel, Brussels, BELGIUM;
    [2] Division of Musculoskeletal Physiotherapy, Department of Health
    Sciences, Hogeschool Antwerpen, Antwerp, BELGIUM; and
    [3] Bio21, Institute of Biomedical Research, University of Melbourne,
    Parksville, Victoria, AUSTRALIA.

    NLM Citation: PMID: 16260962


    PURPOSE: To date, the exact cause of abnormal exercise response in chronic
    fatigue syndrome (CFS) remains to be revealed, but evidence addressing
    intracellular immune deregulation in CFS is growing. Therefore, the aim of
    this cross-sectional study was to examine the interactions between several
    intracellular immune variables and exercise performance in CFS patients.

    METHODS: After venous blood sampling, subjects (16 CFS patients) performed
    a maximal exercise stress test on a bicycle ergometer with continuous
    monitoring of cardiorespiratory variables. The following immune variables
    were assessed: the ratio of 37 kDa Ribonuclease (RNase) L to the 83 kDa
    native RNase L (using a radiolabeled ligand/receptor assay), RNase L
    enzymatic activity (enzymatic assay), protein kinase R activity assay
    (comparison Western blot), elastase activity (enzymatic-colorimetric
    assay), the percent of monocytes, and nitric oxide determination (for
    monocytes and lymphocytes; flow cytometry, live cell assay).

    RESULTS: Forward stepwise multiple regression analysis revealed 1) that
    elastase activity was the only factor related to the reduction in oxygen
    uptake at a respiratory exchange ratio (RER) of 1.0 (regression model: R =
    0.53, F (1,14) = 15.5, P < 0.002; elastase activity P < 0.002); 2) that the
    protein kinase R activity was the principle factor related to the reduction
    in workload at RER = 1.0; and 3) that elastase activity was the principle
    factor related to the reduction in percent of target heart rate achieved.

    CONCLUSION: These data provide evidence for an association between
    intracellular immune deregulation and exercise performance in patients with
    CFS. To establish a causal relationship, further study of these
    interactions using a prospective longitudinal design is required.
  2. cobie

    cobie New Member

    Thanks Tansy. You always manage to find some great articles. WHERE doyou find them ? On the net ? They are much appreciated. cheers Cobie