Chemicals / immune system

Discussion in 'Fibromyalgia Main Forum' started by 139864, Mar 1, 2007.

  1. 139864

    139864 New Member

    You might find this article interesting .I hope so !
    Stay WELL
    Brenda UK


    Centre for Study and Cancer Prevention, Unit of Environmental and Occupational Epidemiology, Florence, Italy.

    BACKGROUND: Many biological and chemical agents have the capacity to alter the way the immune system functions in human and animals. This study evaluates the immunotoxicity of 20 substances used widely in work environments. METHODS: A systematic literature search on the immunotoxicity of 20 chemicals was performed. The first step was to review literature on immunotoxicity testing and testing schemes adopted for establishing immunotoxicity in humans. The second step consisted of providing a documentation on immunotoxicity of substances that are widely used in work environment, by building tables for each chemical of interest (benzene, trichloroethylene, PAHs, crystalline silica, diesel exhausts, welding fumes, asbestos, styrene, formaldehyde, toluene, vinyl chloride monomer, tetrachloroethylene, chlorophenols, 1,3-butadiene, mineral oils, P-dichlorobenzene, dichloromethane, xylene, 1,1,1-trichloroethane, ethylene oxide). The third step was the classification of substances; an index (strong, intermediate, weak, nil) was assigned on the basis of the evidence of toxicity and type of immunotoxic effects (immunosuppression, autoimmunity, hypersensitivity) on the basis of the immune responses. Finally substances were assigned a score of immunotoxic power. RESULTS: Tables have been produced that include information for the 20 substances of interest, based on 227 animal studies and 94 human studies. Each substance was assigned an index of immunotoxic evidence, a score of immunotoxic power and type of immunotoxic effect. CONCLUSIONS: This matrix can represent a tool to identify chemicals with similar properties concerning the toxicity for the immune system, and to interpret epidemiological studies on immune-related diseases.

    PMID: 17036363 [PubMed - indexed for MEDLINE]
  2. 139864

    139864 New Member

  3. lookingoutthewindow

    lookingoutthewindow New Member

    I think this is true. I plan to take the article to my next doctor's visit along with my exposure history. I was overexposed to formaldehyde in the late 90's and oil based deck stain in 2001.
    Thanks!!!
  4. 139864

    139864 New Member

    GOOD FOR YOU !!!
    Brenda ;-)