I've written this before, but thought I would submit it again for review by those interested in Cholestyramine as therapy: In the Allergy Research Group newsletter, "Focus", dated August 2002, I found the following excerpt: "Additionally, binding therapy with the cholesterol-lowering drug Cholestyramine is an option in treating some of these patients. This drug has a complimentary positive charge to the generally negative charge of the neurotoxin and as the neurotoxin-bile complex passes the Sphincter of Oddi where bile is released from the gallbladder, it binds neurotoxins linked to bile, which can then not be reabsorbed. Prolonged use of Cholestyramine has proven to be disappointing in patient out-comes whereby the infection is of a chronic nature. Cycling of Cholestyramine has been utilized (5 days on, 10 days off) or an early AM single dose for several months. In our clinical experience we have found that venous Phospholipid Exchange is one of the most efficient ways of clearing the liver and biliary tree which are paramount in addressing neurotoxic syndromes. Oral use of phospholipids in a Liver Flush is also an effective intervention. Blood thinning agents such as Heparin and Warfarin increase blood flow around the damaged endothelium, however, reconstituting membrane fluidity can directly address coagulation in a natural restorative way. Vibrant healthy membranes will not permit agglomeration." Could the problem be related (not caused by but related) to elevated levels of cholesterol? I have read possible causes of elevated cholesterol being due to lack of bile. There may be a link here as well to levels of cholesterol.