Circulating Blood Volume in Chronic Fatigue Syndrome

Discussion in 'Fibromyalgia Main Forum' started by vickiw, Nov 2, 2005.

  1. vickiw

    vickiw Member

    Circulating Blood Volume in Chronic Fatigue Syndrome

    David H. P. Streeten, MB, DPhil, FRCP, FACP David S. Be11, MD, FAAP

    ABSTRACT. Chronic fatigue syndrome (CFS) is an illness associated with severe activity limitation and a characteristic pattern of symptoms despite a relatively normal physical examination and routine laboratory evaluation.

    The recent description of delayed orthostatic hypotension in patients with CFS, and previous findings of reduced red blood cell (RBC) mass in other patients with orthostatic hypotension not known to have CFS, led us to measure RBC mass and plasma volume in 19 individuals (15 female, four male) with well characterized, severe CFS.

    RBC mass was found to be significantly reduced (p < 0.001) below the published normal range in the 16 women, being subnormal in 15 (93.8%) of them as well as in two of the four men. Plasma volume was subnormal in 10 (52.6%) patients and total blood volume was below normal in 12 (63.2%). The high prevalence and frequent severity of the low RBC mass suggest that this abnormality might contribute to the symptoms of CFS by reducing the oxygen-carrying power of the blood reaching the brain in many of these patients.

  2. mbofov

    mbofov Active Member

    This is very interesting - where did you find it?

  3. vickiw

    vickiw Member


    I did a google search on "blood volume" and this article came up in the results. I didn't copy the whole article here (it was long and there were tables).

    I looked it up because I have low blood volume which my doctor is trying to treat. He diagnosed low blood volume because of my orthostatic postural tachycardia (pulse goes up significantly when going from sitting to standing).

    I was wondering if it would hurt my heart, but according to the abstract, the problem is reduced oxygen to the brain (well that explains the constant fog!)


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