Yesterday, for the first time ever, I tried a large dose of Coenzyme Q10--300 mg. This was based on the advice of someone on the board. (That person's comment was that it made the difference between staying in bed vs. being able to walk to the kitchen, which is certainly a substantial improvement.) Today I'm feeling great.....undoubtedly the best I've felt since I got sick. I'm sure that part of it has to do with a colonic I had several days ago, since my belief is that it flushed the top layer of my yeast (dead and alive) out. But some of it has to do with the Coenzyme Q10, I feel quite sure. I'll have to see how long the effect lasts. However, this is absolutely the same as the experience I had with NADH (also a coenzyme....I didn't realize that until recently). A small dose of NADH (5 mg) did absolutely nothing for me, whereas 20 mg gave me a pretty big bump up. (Now I'm on 100 mg compounded. I'm not sure that it's better than 20 mg, but it's at least as good and substantially cheaper. Let me know if anyone wants to the info on how to get it.) In reading up on this, I realized that coenzymes are only made by the body....they are not at all present in food sources. Since my body is really bad at making other substances (such as all hormones, stomach acid and digestive enzymes), it only makes sense that it wouldn't be able to make coenzymes either. So I'm hopeful that the Coenzyme Q10 will give me a long-term effect as well. (I'm going to get more colonics too.....I think that they have real potential for me.) I should have figured the stuff about the colonics out years ago. (The only way to get anywhere with this stupid disease is to figure out everything yourself, I think.) Still, better late than never. So my new goal is to try as many other coenzymes as possible in high doses, to see if they help as well. I know of one coenzyme, Coenzyme A. I took that in a small dose years ago, with no appreciable improvement. So I'm going to go back to that one at a higher dose and see what happens. Does anyone know of any other coenzymes that I might try? If so, have you had any experience with them? I will keep you informed about whether the Coenzyme Q10 and colonics continue to work. Except with DHEA (about 6 months after I got sick), I've never ever gotten a bump up as big as this one, though. I feel almost normal, although I'm not inclined to push it. Not for the time being anyway. And so I'm hopeful that at least one of the things that I've done this week will indeed stick, if I continue with them. I will keep my fingers crossed. Thanks so much!