Today I looked at the CDC's site for CFS diagnosis -- The Revised Case Definition (abridged version). It reads (this is taken directly from the site): Conditions that Exclude a Diagnosis of CFS Any active medical condition that may explain the presence of chronic fatigue, such as untreated hypothyroidism, sleep apnea and narcolepsy, and iatrogenic conditions such as side effects of medication. Some diagnosable illnesses may relapse or may not have completely resolved during treatment. If the persistence of such a condition could explain the presence of chronic fatigue, and if it cannot be clearly established that the original condition has completely resolved with treatment, then such patients should not be classified as having CFS. Examples of illnesses that can present such a picture include some types of malignancies and chronic cases of hepatitis B or C virus infection. Any past or current diagnosis of a major depressive disorder with psychotic or melancholic features; bipolar affective disorders schizophrenia of any subtype delusional disorders of any subtype dementias of any subtype anorexia nervosa or bulemia nervosa Alcohol or other substance abuse, occurring within 2 years of the onset of chronic fatigue and any time afterwards. Severe obesity as defined by a body mass index [body mass index = weight in kilograms ÷ (height in meters)2] equal to or greater than 45. [Note: body mass index values vary considerably among different age groups and populations. No "normal" or "average" range of values can be suggested in a fashion that is meaningful. The range of 45 or greater was selected because it clearly falls within the range of severe obesity.] My question is, has anyone been denied a diagnosis due to severe obesity? I'm thinking of persons who take medications that cause weight gain in addition to lethergy brought on by pain.