I don't know if you're still reading Jolie's post, and so I thought I'd start a new one for you. Connie, I'm tired, and so will just give a few brief responses. Hopefully you're still reading this post. 1) That seems to me to be a long time even on a mild ABX. Is it working? 2) Is the Respaire and Bacterium working on the sinus infection? Many sinus infections are caused by yeast rather than bacteria. This is something that only the better doctors that I have encountered seem to be aware of. Courses of Diflucan have been extremely helpful to me in this respect, and have shown results within a couple of days. Unfortunately, sinus infections do not go away with a few days of Diflucan.....they keep coming back. Also unfortunately, Diflucan can be hard on the liver (although I don't think this is a problem for me). Fortunately, generic Diflucan is cheap these days. 3) Especially if the Diflucan works on sinus problems, I would suspect systemic yeast. This tends to creep up on CFS patients no matter what they do, especially if they don't follow the stringent rule of absolutely no sugar at any time no matter what. (White flour and fruit juices should be cut back.) The use of antibiotics makes the likelihood of yeast even higher. Even if she has tested negative for yeast, I would suggest following anti-yeast recommendations anyway. These include 1) LOTS of probiotics (10 billion microorganisms per day....this is about 10 regular capsules, but I got no results until I increased (upon my MD's recommendation) to this dosage, 2) anti yeast supplements (oregano oil, pau d'arco, goldenseal, citrus seed extract, etc., preferably rotated; Nystatin if you want to add it), 3) strict no sugar diet. if this results in a herx (mostly mental fogginess), you can assume there's a problem. 4) If you're treating for yeast and herxing becomes unbearable, a colonic (colon hydrotherapy) can help. Keeping regular and drinking lots of water can also help. 5) Maybe see if you can lower the Prozac dosage. If it's for pain, DLPA (an amino acid) may help. (This is helpful for depression.) St. johns Wort and 5 HTP can also help. 6) Klonopin has been far, far better than Trazodone in helping me to get really restful sleep. This is a standard CFS protocol. Unlike other sleeping aids, Klonopin (and its cousin Xanax) help the body to get restful sleep.....not just sleep. I have been on it for years (2 mg per night) with no addiction. I've not heard of anyone else becoming addicted for this purpose. It's pretty common in the literature....read up on it. 7) I agree wholeheartedly with your conclusion about Provigil. I do not believe that it is the right drug for most CFS patients, and may be harmful in the medium to long run. 8) Going back.....if you can get any systemic yeast under control, any sinus yeast infections will eventually fade on their own. (This does not mean that Diflucan is not appropriate for a short-term treatment.) Vaginal infections MAY eventually also heal, although this takes much more time. 8) That sounds like an extremely aggressive Acyclovir initial dosage to me. People have crashed big-time on doses like that, and given up on the drug entirely. This is especially the case since acyclovir often has side effects, but much more because of the possibility of a herx. I would advise starting very small and then working your way up, based on the experiences I've read on this board. Considering starting low and then working up seems to me very, very important if you go this route. 9) This seems to me like a lot of drugs for a young person to try. Taking her out of school is for a while is a good first step. I'm still inclined to encourage her to rest as much as possible and to let her body heal naturally to the extent possible. I've only resorted to the AV's after 11 years with this illness, and because I am convinced that nothing else will get me past a 6/7. I've tried every other remedy I could find before resorting to them, though. In your daughter's case, there's at least some chance she will recover (REALLY recover, not just go into remission) if she takes the time to rest now. I'm afraid that too many drugs will stress her system so much that this natural process won't be allowed to happen. Explore alternative remedies to every extent that you can, I would recommend. 11) My conclusion is that with the AV's, having good liver support is essential. I would see if you can find one that does not prompt an allergic reaction before you start the AV, if indeed you do use the AV at this time. Options are Immune Pro Rx (i've had great luck with this, but others on the board can't stand it at all), milk thistle (silymarin) and the Chinese herb bupleurum. 12) If you do the AV, I would suggest your reading my posts on Famvir to see what to expect. (Jolie's on Valtrex may be less useful because---apparently due to going on too many drugs at once---she flamed out very quickly.) 13) You mention an "underlying viral infection" as if it were something that might be fixed with a short course of av's. It seems increasingly clear that CFS sufferers have a problem with their immune system, and that viruses of all sorts will continue to attack even after the virus that you think is the problem is eradicated. This became clear to me when I did a test on my immune system by ImmunoSciences. If you would, please look it up in the content section of the board archives. If you can't find it, I will help you. Hopefully your doctor can order it. I found it the most informative test I've ever done in allowing me to understand my illness. It's less than $400 out of pocket, and most insurance seems to pay for it. 14) If your daughter does well over Christmas break, I still would suggest giving her a prolonged break from school in order to continue her recovery. Studying at home probably is okay, as long as she does so within her limits. i've stated my thoughts on this before and don't need to elaborate further. 15) Congratulations on finding a "country doc" that will allow you to try different things. All CFS patients should be so lucky! I'm from Indiana myself, and I think the docs there are, on the whole, really great there. _Far_ better than the ones I've found in Chicago or heard about on this board, anyway. Good luck! Keep us informed.