Cortisol levels

Discussion in 'Fibromyalgia Main Forum' started by clerty, Mar 22, 2007.

  1. clerty

    clerty New Member

    I hope it is ok to post this I found it very interesting

    OBJECTIVE: To compare the momentary association between salivary cortisol
    levels and pain, fatigue, and stress symptoms in patients with fibromyalgia
    (FM), and to compare diurnal cycles of cortisol secretion in patients with
    FM and healthy control subjects in a naturalistic environment.

    METHODS: Twenty-eight patients with FM and 27 healthy control subjects
    completed assessments on salivary cortisol levels and pain, fatigue, and
    stress symptoms, 5 times a day for 2 consecutive days, while engaging in
    usual daily activities. Only those participants who adhered to the protocol
    (assessed via activity monitor) were included in the final analyses.

    RESULTS: Twenty FM patients and 16 healthy control subjects adhered to the
    protocol. There were no significant differences in cortisol levels or
    diurnal cortisol variation between FM patients and healthy controls. Among
    women with FM, a strong relationship between cortisol level and current
    pain symptoms was observed at the waking time point (t = 3.35, P = 0.008)
    and 1 hour after waking (t = 2.97, P = 0.011), but not at the later 3 time
    points. This association was not due to differences in age, number of
    symptoms of depression, or self-reported history of physical or sexual
    abuse. Cortisol levels alone explained 38% and 14% of the variation in pain
    at the waking and 1 hour time points, respectively. No relationship was
    observed between cortisol level and fatigue or stress symptoms at any of
    the 5 time points.

    CONCLUSION: Among women with FM, pain symptoms early in the day are
    associated with variations in function of the
    hypothalamic-pituitary-adrenal axis.


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