Curemisinin - Interesting

Discussion in 'Fibromyalgia Main Forum' started by Elisa, Dec 28, 2009.

  1. Elisa

    Elisa Member

    Hi all,

    Based on Dr Cheney's current recommendations - of using curcumin and artemisinin - I found this product - I am actually looking for a curcumin patch...Thought it was interesting enough to comes in oral and nasal forms. Has anyone tried it?

    Curemisinin™ (from Bioponic Phytoceuticals) uses a “combination of natural products” approach by combining the anti-malarial effects of known (and currently utilized) effective herbal agents: Artemisia (source of artemisinin), Turmeric root (source of curcumin) and Cinchona bark (source of natural quinine alkaloids). In combination, this formulation offers a useful remedy to address the problems of malaria. In addition, Bioponic Phytoceuticals’ use of a nasal delivery system allows the liquid remedy to be delivered directly to the brain via the nasal membrane. This may have a significant impact on Cerebral Malaria, a condition that especially effects children and is deadly if not treated.

    Artemisinin is a compound used to treat multi-drug resistant strains of falciparum malaria. The compound is found in the shrub Artemisia annua and is used in traditional Chinese medicine. In China during 1979, Artemisinin trials were conducted wherein 2,099 patients infected with P. viva and P. falciparum were tested. Artemisinin had good therapeutic effects and improved or cured all patients. Furthermore, the treatment with Artemisinin was without any obvious side effects. Artemisinin is also effective in cerebral malaria. Body temperature of patients normalized within 72 hours, and asexual parasites were eliminated within 72 hours. Mutations conferring resistance to artemisinins have never been documented and are therefore much less likely to occur than mutations to some other drugs. Artemisinins are a particularly effective partner drug because they are more active than any other antimalarial. In addition, artemisinins have broad stage specificity and can be used to treat severe as well as uncomplicated malaria. The World Health Organisation has recommended that a switch to Artemisinin Combined Therapies (ACT) should be made in all countries where the malaria parasite has developed resistance to chloroquine.

    A compound isolated from the turmeric plant, has been found to possess qualities that can effectively fight malarial parasites, including the dreaded drug-resistant forms of Plasmodium falciparum or cerebral malaria, according to the intensive study being carried out by scientists of the Department of Biochemistry, Indian Institute of Science at Bangalore. Prof G Padmanabhan and his team found that treatment with a Curcumin based combination leads to complete clearance of parasites in blood and total protection against mortality in experimental animals. Scientists at the Indian Institute of Science (IISc) in Bangalore and the University of Michigan Medical School, United States have shown that curcumin inhibits drugresistant forms of P. falciparum. The findings have been published in Biochemical and Biophysical Research Communications in January 2005. (Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN. Curcumin for malaria therapy. Biochemical and Biophysical Research Communications. 2005;326(2):472- 474).

    Artemisinin and Curcumin
    The rationale for using compounds in combination is well established. The probability of a parasite arising that is resistant simultaneously to multiple compounds with unrelated modes of action is the product of the per parasite mutation frequencies multiplied by the total number of parasites exposed to the compounds. Artemisinin and Curcumin show an additive interaction in killing Plasmodium falciparum. Artemisinin derivative-based combination therapy (ACT) has been advocated as the therapy of choice to handle widespread drug resistance in Plasmodium falciparum malaria, at the same time preventing recrudescence due to artemisinin monotherapy. The curcumin-artemisinin combination may prove superior from several perspectives. Both are from natural sources of long-term use, and no resistance is known to curcumin.

    In a paper published in Antimicrobial Agents and Chemotherapy journal, Padmanaban and Rangarajan along with D.N. Nandakumar, P.G. Vathsala and V.A. Nagaraj said the advantage of the combination was manifold. Both were derived from natural sources so were free from side- effects and toxicity. Curcumin is tolerated at very high doses. With the malaria parasite developing resistance to first line and second line drugs like chloroquine and antifolates, artemisinin and its derivatives have remained the only treatment options.

    Cinchona Bark
    (Quinaquina officinalis, Quinaquina lancifolia, Quinaquina coccinea) Natural quinine compounds extracted from Cinchona are making a comeback in the management and treatment of malaria. Malaria strains have evolved which have developed a resistance to the synthesized quinine drugs. It was shown in early studies that an effective dose of natural cinchona bark extract elicited the same antimalarial activity as an effective dose of the synthesized quinine drug. Scientists are now finding that these new strains of drug-resistant malaria can be treated effectively with natural cinchona bark extracts. As evolving pathogens develop widespread resistance to our standard antibiotics, antivirals, and antimalarial drugs, the use of the natural medicine in cinchona bark is being revisited, even by the World Health Organization.

    God Bless,


    [This Message was Edited on 12/28/2009]
  2. herbqueen

    herbqueen New Member

    Interesting with overlap with lyme and coinfections alternative treatments and this product....
  3. simonedb

    simonedb Member

    I tend to feel worse on artesunate but then better
    curcumin also felt bad when tried it recently, but i feel bad on a lot of stuff
    that is interesting about the quinine, I read a book about civil war times and they used that a lot to heal the sick then, seemed like there must be something to it, i went and bought club soda after reading that : ) but no gin

    i would be open to trying this, sounds like good stuff but i would do in small dose and expect feeling bad would have to pulse it
  4. AuntTammie

    AuntTammie New Member

    I honestly don't know much about quinine, but when reading this thread, I did remember having read or heard somethign bad about it.....did a quick google search and the first thing I found said the following ( it also said that the use of it for malaria is justified bc malaria can be so much worse than the side effects):

    Quinine side effect risks

    Quinine poses serious and potentially deadly risks. These side effects clearly outweigh the potential benefits of using this drug for the treatment or prevention of nocturnal leg cramps. Quinine adverse reactions include:

    * Cardiac arrhythmias. This potentially serious condition causes irregularities in the sequence of heartbeats. Quinine cardiac arrhythmias can produce anxiety and, more seriously, impair the heart’s ability to properly pump blood. Drug treatments, artificial pacemakers, and other treatments may be necessary to address this condition.
    * Thrombocythemia. This is a quinine side effect that causes the body to produce excess platelets, which leads to abnormal blood clotting or bleeding. This condition doesn’t often produce symptoms, though it can cause the formation of blood clots. Symptoms of blood clots can include tingling the extremities, cold fingertips, headaches, dizziness, and weakness. Nosebleeds, bruising easily, digestive tract bleeding, and gum oozing are also possible symptoms. Drug treatment is often required for this serious condition.
    * Cinchonism. This condition is characterized by headaches, nausea, ringing of the ears, visual impairment, stomach pain, rashes, diarrhea, vertigo, and vomiting.
    * Hypersensitivity reactions. Symptoms of this quinine side effect include hives, skin flushing, fever, facial swelling, and more.
    * Drug interactions. When quinine is taken concurrently with mefloquine, it can increase the risk of seizures, heart arrhythmias, and other serious reactions. Other concurrent drug use may also pose serious risks.
    * Contraindications. Patients with any of these condition may be at an increased risk of quinine side effects: tinnitus (or ringing of the ears), certain visual conditions, and more.
    * Quinine overdose. Another serious risk posed by quinine use is the potential to receive a toxic dose. The difference between correct dose and overdose is very small with quinine. If a patient suffers a quinine overdose it can cause serious damage and may be lethal. Symptoms can include gastrointestinal side effects, cardiotoxicity, visual disturbances, central nervous system disturbances, and more.

    Since 1969, the FDA has received 665 reports of serious adverse reactions caused by quinine. The agency has received reports of almost 100 deaths caused by quinine. In light of these grave risks, the FDA urges patients not to use quinine for the treatment or prevention of leg cramps.

    Recent FDA action over quinine

    On December 11, 2006, the FDA ordered that all manufacturers of unapproved quinine drugs immediately stop marketing these dangerous products