I have been on an anti-depressant (Zoloft) which was supposed to help me lose weight as well as help with depression issues. In the beginning I did lose a few pounds but I have since gained about 10! or more. I have recently weaned myself off to see if it caused the weight gain but it's too soon to tell however, I am a basket case and feel like I need to be on an A/D. Has anyone lost weight while on Cymbalta? I'm thinking of asking my dr. to rx cymbalta for me. Maybe it will help in more ways than ONE!