I feel like a niggling pest with all these questions about these antidepressants but here's one more. Effexor and Cymbalta work on serotonin and norepenephrine, I understand. However it is my understanding that they only effect norephenephrine once a fairly high dose is reached and up to that point they are doing the same as Prozac would. Can anyone (everyone!) comment on this? And have you read at what dose the effects on the norephephrine kick in? Thank you!