Sorry for the umpteenth thread on this, but since the search engine only searches by subject and not by posts, I couldn't find the exact answer that I needed... So I've been on 60mg daily for 2 months now. The fatigue was debilitating at first, but that wore off. Now, my pain is marginally better, I sleep better at night (i.e., I don't wake up every hour on the hour), and I've been told that I seem to handle my sick days better, too. Problem is that I still get exhausted about 4 - 8 hours after I take the pill. I just feel wiped out, either nodding off at my desk at work, unable to concentrate... or needing an early night nap, barely keeping my head up through dinner. I've tried taking the medicine at dinner instead of breakfast, but what I found was that it made it very difficult for me to wake up. Too heavy-headed. And my doctor suggested taking a narcolepsy-related pill during the day if I could take the cymbalta at night, but that's simply not a road that i want to get on (i.e., taking one to sleep and another to stay awake. Bad cycle, imo.). So has anyone else had this problem and if so, have you found relief? How? Other suggestions? I am thinking that I need to exercise more (don't we all...) and I'll start with the treadmill tonight... if I have the energy. I am also B-12 and iron anemic and I know that I need to do a better job of taking those supplements as well. Thoughts? Thanks!