CYP2D6 geneRegulates how AD meds communicate to brain

Discussion in 'Fibromyalgia Main Forum' started by razorqueen, Nov 9, 2006.

  1. razorqueen

    razorqueen Member

    Ok,
    I hope this is okay to do. I found this post on a drepression board, and found out about some vital info for people with depression, espically if it is resistant to treatment, like my husbands.

    If this is not aloud, please delete and forgive me! Just trying to help!

    Raz

    ___________________________________________________________






    Okay, for all you folks on antidepressant meds, prick up your ears! CYP2D6 is a gene. In short: it regulates how neuroleptic (sp?) meds are communicating and traveling to the brain...my definition may be a little sophomoric, but here's the short and the long: Have it tested. If you are on ANY type of antidepressant, have it tested. If you are considering going on antidepressants, have it tested. I'll say it once more: have it tested. I was/am med-resistant...to EVERYTHING. Oh, the side-effects were there, but no discernable dent had been made in my depression (misdiagnosed as bi-polar type 2; which is beside the point here). And I had no idea why, and the medical professionals could offer no answers...Until the day I heard that odd string of letters and numbers: CYP2D6.

    CYP2D6…here's the skinny made simple [with a little help from my wife who is a Biochemical Geneticist, and the one who figured this out…with no help from my doctor, I might add]: the CYP2D6 gene has two alleles, like two little hands that send medication to the brain. If one of the “hands” is malfunctioning (as is one of mine), then you are considered an "intermediate metabolizer." This can have serious repercussions...first, there isn't enough medication getting to your brain. Most of the time, a patient will simply report this as, "The drug isn't working." So the doctor will increase the dosage. Bad news. Here's why: you can have a serious backup of the medication in your bloodstream or liver, leading to harsh interactions with other meds, higher instances of negative side-effects, and, in my case, a near-lethal prescription dose (can you say four day coma? I couldn't...I was in a coma).

    What makes increasing the dosage even worse (insult to injury, more salt in the wound) is the drug STILL won't get to your brain. The hose (the remaining, functioning allele) simply isn't large enough to let enough medication through. Again, I'm shying away from clinical descriptions of how this all works on a genetics or neural-chemical level because it's really dull to read (so don't flame me). For me (and I admit I'm probably an extreme example), the result was four years on EVERY class of drug (SSRIs, MAOIs, tricyclics...and even talk of ECT!!!), and nothing to show for it but six suicide attempts. Also, I was led down that circular pharmaceutical path where you take one drug, have side effects, so another drug is prescribed to take care of that, but then there are new side effects, and yet another drug is prescribed to take care of those! It was an endless spiral, and, at the height of it, I was taking 6 different meds at once, several times a day!!!...Each one trying to dampen the undesirable effects of the last. Nightmarish doesn't even begin to describe it.

    Sooooooo, eight months ago (after being genotyped and diagnosed as an "intermediate metabolizer"), I made the decision (under doctor's care and supervision--VERY IMPORTANT) to stop all of my meds (except xanax, for anxiety, which works differently from the other meds). I suffered the worst withdrawals imaginable. Several abstracts I've read on PubMed have likened antidepressant withdrawal on par with that of heroin or cocaine. Fun. But I'm here to tell you, I'm better for stopping the meds. The drugged "haze" has lifted. My energy is SLOWLY returning. And people around me have been saying more and more, "You seem like the old you." Which they mean as a good thing. I'm even going back to work (interviewed last week...now I have to make my decision of where). That's not to say that my depression isn't still with me. It is. It's like a shadow. But without all the crappy side-effects and other problems the medications were causing, it feels more manageable (at least during the day...nighttime is a different chapter altogether).

    So, back to CYP2D6. There is a very good chance that your doctor isn't even aware of this kind of genotyping, of CYP2D6 (called "sip"2d6, for short), or there's even a test available. There is a lot of literature going around right now about this...check it out on the web. www.PubMed.gov is a good place to start (try a search like "cyp2d6 and antidepressants" and see what comes up). The major consensus is: anyone who is (or is considering) taking antidepressants, should have this test done. It will give your doctor a better idea of a base starting point (how MUCH medication you should have), or if you should even try antidepressants at all. Here is a quote from one of the studies: "The therapeutic drug monitoring and the genotyping findings resulted in recommendations to physicians to alter the medication strategy of 146 (64%) patients." The doctors altered the medication strategy of over HALF the patients in the study after they were genotyped. Simply, they needed an adjustment to their dosage. Pretty important information, I think.

    (Here's the link to that abstract: http://www.ncbi.nlm.nih.gov/entrez/query.fcgidb=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=17050797&query_hl=4&itool=pubmed_docsum)

    Getting tested is simple (nothing exotic), just a blood test, and with a prescription should be covered by insurance. For my part, my body has this little malfunction, and it won't allow me the luxury (if it can be called that) of benefiting from antidepressant medication. It was a long road that felt straight and steeply inclined, but (turns out) it was only a frustrating circle. So, if you're in early stages of antidepressants, get the test. If you seem resistant to the meds, as I was, this test is VERY important. It was the silver-bullet that told me the most important piece of information: why. And if you've been on meds a long time and they seem to be working, you may not think you need this...but, then again, it's never a bad idea to have all the facts. Again, it's a simple blood test. You can have it done the next time you go in to have your blood levels checked. Also, I don't want any of this to sound alarmist. My case was peculiar and harsh...but not all are. The important thing I'm trying to express to you is this: you may not be getting the right thereputic dose of medication you need to help your illness...or, in my case, your medication may be causing you to get worse. Being genotyped can be a huge leap in understanding how your body is dealing with the meds.

    And, of UTMOST importance, if your doctor does not know about this test, demand he/she find out. Don't ask, don't gently urge, DEMAND IT!!! They're YOUR doctor. This is YOUR treatment. You have the RIGHT to know all the facts, and you have the right to ask ANY question. I cannot stress this enough. Your doctor is just a doctor...just a person with a job (and a huge student loan). He/she may not be up on the latest literature (although, they should be). And if you're not getting the right type of feedback, the right kind of give-take, then find another doctor. You are allowed to fire them (in fact, say that. Say, "Doc, you're fired." It feels pretty good). You are allowed to go elsewhere for treatment. That's what I had to do.

    So...good luck, out there. I hope this helps and enlightens. My thoughts are with each of you...every day.

    -Steven
    kelliek likes this.
  2. razorqueen

    razorqueen Member

    no comments????
  3. karinaxx

    karinaxx New Member

    since so many with cfids are getting Antidepressants prescribed and we do have such high ratio of allergic reaction, this is indeed important.
    i am not taking any of those drugs; believe strongly they should just be taken , when absolutly needed and than with caution. this just confirms it.
    thanks karina
  4. razorqueen

    razorqueen Member

    that there is no interest in this,,,,,
  5. deliarose

    deliarose New Member

    do u know what lab does the testing? Can u get it thru Quest?
    cheers
    delia
  6. sleepyinlalaland

    sleepyinlalaland New Member

    but the format is really hard to read, because I'm forced to "arrow" back and forth to read whole lines. I'm gonna copy this to my own document and try to read it that way.

    I don't know if you can change the extra-long-line format (how does that happen, anyway?), but that would be helpful for other potential readers.

    Thanks for posting it.
  7. razorqueen

    razorqueen Member

    You know, I don't know how or why it copied this way. And I am slightly computer illerate so I don't know of anyway of changing it!

    It is annoying having to move the screen back and forth that way! I totally agree!

    Raz