D Ribose

Discussion in 'Fibromyalgia Main Forum' started by Rugratfun, Aug 11, 2008.

  1. Rugratfun

    Rugratfun New Member

    Can anyone tell me what there experience with D-Ribose is in reference to CFS? Does it help? How long have you tried it for?

  2. meditationlotus

    meditationlotus New Member

    helps with my energy and stamina. I take about 1/2 a scoop per day and combine it with coq10, acetyl-l-carnitine and alpha lipoic acid. This combo helps the mitochondria in cells to make energy.

    Dr. Teitelbaum recommends 3 scoops per day. It is sugar and I am hypoglycemic, so I just consume a little. Also, it is expensive.

    Hope that this helps.
  3. Rugratfun

    Rugratfun New Member

    Thanks...I really need the extra boost and am going to try it..thanks for the help..
  4. msSusan

    msSusan Member

    Does anyone know what d-ribose is derived from?

    I had read it may be derived from corn and I have a corn intolerence.

    Does anyone use it strictly for FM muscle pain w/success?
  5. charlenef

    charlenef New Member

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    Supplement Spotlight: Ribose

    June 03, 2000 - By Lisa Turner — Vitamin Retailer April 2000
    Ribose, a naturally occurring sugar found in all cells in the body, is an essential ingredient in stimulating energy production. Ribose can benefit anyone from weekend warriors to working moms. Studies have shown that ribose boosts physical energy levels, reduces recovery time following exercise, increases performance and endurance, and reduces post-exercise stiffness and cramping. It also has applications in cardiovascular health, and studies show it can benefit those suffering from certain cardiovascular disorders, including ischemia (diminished blood flow to the heart).

    What is it?

    Ribose is a pentose (a five-carbon sugar) found in all cells in the body. It serves as a precursor to the production of ATP (adenosine triphosphate), the primary source of energy required for all living cells. ATP, composed of adenosine joined with three molecules of phosphate, is vital in controlling energy charge in the heart and muscle cells, and in regulating the function of enzymes, electrolyte activity and other important cell functions.

    Where does it come from?

    Until recently, ribose was prohibitively expensive to manufacture, and was used primarily in the pharmaceutical industry. New bacterial fermentation processes that allow the conversion of corn syrup into ribose make mass production of ribose simpler and less expensive. Ribose is now produced through a sophisticated fermentation process with food-grade microorganisms, which use glucose to produce ribose. The ribose is then purified, crystallized, dried and milled.

    How was it discovered?

    Researchers have known about ribose metabolism since the 1930s, but its importance wasn't recognized until nearly 20 years later. Research on ribose metabolism began in the 1950s with early animal studies. In 1958, studies on humans began; the early focus on ribose was in the area of cardiovascular health. More recently, researchers have begun examining the effects of ribose on athletic performance.

    What is it good for?

    Ribose has two primary applications: cardiovascular health and athletic performance. When blood flow to the heart is diminished (ischemia), or when the heart is under low oxygen conditions (anoxia), the ATP stores in the heart are degraded rapidly. Supplemental ribose can rebuild ATP levels in the heart, and can improve the quality of life for people suffering from certain cardiac conditions.

    Ribose can also improve athletic performance. Intense muscular contractions can cause a temporary lack of adequate blood flow and oxygen, creating a loss of the nucleotides needed to rebuild ATP in the cells. Ribose can rebuild ATP stores in the cells leading to enhanced energy levels, increased performance and endurance, shorter recovery time and less post-exercise stiffness and cramping. Additionally, it is possible that ribose may have potential applications in treating neurodegenerative diseases including Alzheimer's and Parkinson's.

    The body uses ribose to manufacture glucose, required for energy production, and to form pyruvate, which enters the cells in an energy-producing process called the Krebs cycle. Ribose is also a key compound used to form nucleotides, essential compounds needed to produce energy for muscle cells, fuel metabolic reactions, synthesize protein, glycogen and nucleic acids (RNA and DNA), and transfer energy between cells to fuel normal activity. Ribose is also used to form cyclic nucleotides, compounds that are necessary for controlling electrolyte activity, including regulating the contraction and relaxation of heart and muscle cells.

    How does it work?

    The primary source of energy in the body is a compound called ATP, as described earlier. The "adenosine" portion of ATP is composed of a molecule of adenine and a molecule of ribose. The "triphosphate" portion of ATP consists of three phosphate molecules. When one of the phosphate molecules breaks off, energy is released. The ATP molecule then becomes ADP (adenosine diphosphate), consisting of adenosine and two phosphate molecules.

    ATP stores are limited — in most cases, the body can hold only about 90 grams of ATP, enough to supply maximum energy for about 10 seconds. To overcome this limited ATP supply, the body uses various forms of recycling, including adding a phosphate molecule to the "leftover" ADP to form another ATP molecule. During aerobic metabolism, in the presence of sufficient oxygen, the recycling process works fairly well. However, during high- intensity anaerobic training like body building, the mechanisms differ. Under anaerobic conditions, cells get the extra phosphate molecule from creatine phosphate stores in the muscles.

    It sounds efficient, but the ATP-creatine energy cycle can only supply about 30 seconds of maximum energy, because creatine stores are depleted rapidly. After creatine runs out, the body relies on a series of additional, complex reactions in an attempt to rebuild ATP stores. One of these is called the "myokinase reaction." In this energy pathway, two ADP molecules and one AMP (adenosine monophosphate, which contains one phosphate) molecule are combined to form an ATP molecule. Other mechanisms exist to help maintain ATR The salvage pathway uses ribose and AMP metabolic by-products to maintain ATP stores, or manufactures new ATP in a reaction called the de novo pathway.

    What do studies show?

    A number of studies attest to the effectiveness of ribose in promoting energy, both in cardiovascular and athletic performance applications. More than 150 peer-reviewed published studies point to the ability of ribose to boost ATP levels and improve performance of heart and muscle cells in the presence of impaired blood flow or reduced oxygen. Some highlights follow:

    Studies have shown that significant reduction in ATP occurs during maximal exercise in humans. ATP levels in thigh muscle may be reduced by 13 to 37 percent following intense exercise, and up to 47 percent in other muscles, suggesting the usefulness of ribose to increase ATP stores.
    Ribose effectively increases ATP production in muscles. One study found that ribose boosted ATP production in both fast-twitch and slow-twitch muscles by 3.4 to 4.3 times.
    One study found that, following a heart attack, those patients who took supplemental ribose had normal ATP levels and heart function within two days. Patients who did not receive supplemental ribose showed depressed heart function after four weeks.
    One study induced myocardial ischemia in two groups of test animals, decreasing ATP levels by 50 percent. A test group of animals received ribose. In 24 hours, the ribose group had an 85 percent recovery of ATP levels, while no significant recovery was noticed in the control group.
    A small, unpublished study examined the effect of supplemental ribose on performance and recovery during and after high-intensity exercise. The study showed that peak power was 9.9 percent higher and mean power was 9 percent higher in the subjects who took ribose. Muscle biopsies showed that those taking ribose used their energy stores more effectively and recovered quicker after exercise.
    In a human pilot study (sponsored by Nutratech), athletes were given Ribocell ribose supplement. Preliminary results showed significant improvements in peak and average power performance. Currently, Nutratech is conducting the second phase of this study and adding 20 subjects.
    Is supplementation necessary?

    Only trace amounts of ribose can be found in foods, primarily meat, so supplemental ribose can be beneficial. Normally, the body produces whatever ribose it needs, but ribose levels can become depleted during intense exercise. Supplemental ribose can help increase ATP levels following high-intensity exercise or periods of diminished blood flow in the body.

    How safe is it?

    Ribose is generally considered extremely safe. Doses of up to 60 grams have been shown to be safe. A few reported side effects include diarrhea and mild, transient hypoglycemia at very high doses (more than 25 grams per dose). Most excess ribose is excreted in the urine.

    Is it available in combination formulas?

    Ribose is available in single formulations, and in combination with supplements associated with energy production, especially those that require optimal levels of ATP, including pyruvate, L-carnitine and other energy supplements. Ribose is most commonly combined with creatine which — as was noted — supplies phosphate molecules.

    Because it's a simple sugar, ribose is rapidly absorbed and easily assimilated. It may be taken in various forms, but hot protein drinks should be avoided, since, when heated, ribose may react with amino acids in protein and can become less effective.

    What's the recommended dosage?

    It is generally recommended that ribose be taken every day, to maintain steady cellular ATP levels. A total of 3 to 5 grams per day is generally recommended, or 2 grams before and 2 grams after workouts. Serious competitors or those with cardiovascular concerns may take 5 to 10 grams per day, starting with the lower dose and increasing gradually. VR


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