I agree with the post about the D-Ribose, it helped me at first but after a while it seemed to lessen the effect, I was very disappointed, but will stay with it for while. I buy it online at Vitacost.com for 26.95 s+h.4.99.......I have battled CFS since 1983, and have tried various vitamins and supplements; the first 2 years were pure hell. I have found that exercising is a must, you have to ease into it. I feel good now most of the time, except when I catch a cold, flue or I am under stress, everything resurfaces, which is always very devastating and extremely frustrating for me, the fatigue is enormous, lasting anywhere from 2-3 weeks. Thanks for letting me post this. Kitty.