My rheumy sent me back to the sleep specialist, hoping that the SS would find something to improve with sleep that would take away the pain that isn't RA. Rheumy suggested SS have me try Xyrem. Well, SS is somewhat reluctant because insurance will fight it because of cost, but also because while he tries to work with rheumy's theories about sleep and fibro as much as he can, his oath is to "do no harm". He doesn't think I have much left in the way of sleep issues since I am on CPAP for severe apnea. I had an incredible 20% Stage IV during the titration study, which is amazing for anyone during a titration study. So he doesn't think even another sleep study would show anything but is willing to write one up for me. I am using Ambien as needed to help sleep, although I have never had to sleep 8 hours in order to wake up from it. In fact, it hardly even causes me to feel groggy. It appears Xyrem has some dangers associated with it. Seizures, especially. How much does anyone know about the possible dangers of Xyrem? If there isn't a serious sleep problem, would it increase the risk of seizures?