Hi, I'm new to this board, not new to fibro or migraines. Ive been taking Topamax as a preventative since April now my dose is 300mg. My neuro wanted me to go up to 400mg, but I said enough cognitive damage at this dose, hair loss too. He said hair loss is not a side effect of Topamax. (Well it is!) Quite a few others who take it have commented on it also. The Topamax had been working until recently, it still helps my abortive work fairly well, where abortives just did nothing for me before I started on it. So now he wants me to start on DepakoteER at 500mg. First he told me for 3 days, then increase it to 1,000mg. I called him back & told him I was not comfortable with that. He said OK, go for a week, then increase. I had to have some other medical tests done, he said to wait til I get results of those first before I start. He never told me about side effects of Depakote. When I spoke to him about dosage I asked about the side effects again, (this time I knew them!) he explained the extended release has less side effects than the regular Depakote. To top things off the 500mg pill is a huge horse pill & I have been having problems with my throat. Neuro said they just came out w/ 250ER, he doesn't know if it's smaller, I'll have to talk to my pharmacist. Neuro thinks it will be a bother to swallow 4 250mg when the dose is 1000mg. (Better than choking on the horse pills) So my question is, has anyone had any experience with DepakoteER. Just wondering what some experiences are? Thanks for sharing any info.